2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. 7-Methyladenine

7-Methyladenine  (Synonyms: N7-Methyladenine)

Cat. No.: HY-116496 Purity: 98.13%
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7-Methyladenine (N7-Methyladenine), a methylated analog of Adenine (HY-B0152), is a biomarker of DNA damage from exposure to methylating agents.

For research use only. We do not sell to patients.

7-Methyladenine Chemical Structure

7-Methyladenine Chemical Structure

CAS No. : 935-69-3

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7-Methyladenine Related Antibodies

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Description

7-Methyladenine (N7-Methyladenine), a methylated analog of Adenine (HY-B0152), is a biomarker of DNA damage from exposure to methylating agents[1].

In Vitro

The higher acidity of 7-Methyladenine leads to its enzymatic cleavage from damaged DNA, and due their instability as nucleosides, it is therefore possible to isolate and determine these methyladenines as simple nucleobases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Methyladenine Related Antibodies
In Vivo

The concentration of 7-Methyladenine is increased in the urine of rats exposed to methylating agents such as dimethylnitrosamine, N-nitroso-N-methylurea, methylnitronitrosoguanidine and dimethyl sulfate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

149.16

Formula

C6H7N5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=C2N(C=NC2=NC=N1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 5.56 mg/mL (37.28 mM; ultrasonic and warming and adjust pH to 3 with 1M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7042 mL 33.5211 mL 67.0421 mL
5 mM 1.3408 mL 6.7042 mL 13.4084 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.7042 mL 33.5211 mL 67.0421 mL 167.6053 mL
5 mM 1.3408 mL 6.7042 mL 13.4084 mL 33.5211 mL
10 mM 0.6704 mL 3.3521 mL 6.7042 mL 16.7605 mL
15 mM 0.4469 mL 2.2347 mL 4.4695 mL 11.1737 mL
20 mM 0.3352 mL 1.6761 mL 3.3521 mL 8.3803 mL
25 mM 0.2682 mL 1.3408 mL 2.6817 mL 6.7042 mL
30 mM 0.2235 mL 1.1174 mL 2.2347 mL 5.5868 mL
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7-Methyladenine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Methyladenine935-69-3N7-MethyladenineDNA Alkylator/CrosslinkerBiomarker of DNA Methylating AgentsDNA damageInhibitorinhibitorinhibit

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