2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor Endogenous Metabolite Drug Metabolite
  4. 5α-Tetrahydrocorticosterone

5α-Tetrahydrocorticosterone  (Synonyms: 5α-THB)

Cat. No.: HY-113364
Handling Instructions Technical Support

5α-Tetrahydrocorticosterone (5α-HB), an endogenous steroid, is a glucocorticoid receptor (GR) agonist and a metabolite of Corticosterone (HY-B1618). 5α-Tetrahydrocorticosterone is an effective topical anti-inflammatory agent in vivo. 5α-Tetrahydrocorticosterone reduces metabolites that bind to GR-Corticosterone and its 5α-reduced metabolites in rat hepatocytes, with a Kd of 268 nM. 5α-Tetrahydrocorticosterone can be used for research on inflammatory skin diseases.

For research use only. We do not sell to patients.

5α-Tetrahydrocorticosterone Chemical Structure

5α-Tetrahydrocorticosterone Chemical Structure

CAS No. : 600-63-5

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Based on 1 publication(s) in Google Scholar

5α-Tetrahydrocorticosterone Related Antibodies

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Description

5α-Tetrahydrocorticosterone (5α-HB), an endogenous steroid, is a glucocorticoid receptor (GR) agonist and a metabolite of Corticosterone (HY-B1618). 5α-Tetrahydrocorticosterone is an effective topical anti-inflammatory agent in vivo. 5α-Tetrahydrocorticosterone reduces metabolites that bind to GR-Corticosterone and its 5α-reduced metabolites in rat hepatocytes, with a Kd of 268 nM. 5α-Tetrahydrocorticosterone can be used for research on inflammatory skin diseases[1].

In Vitro

5α-Tetrahydrocorticosterone (0.001-100 μM) reduces metabolites that bind to GR-Corticosterone and its 5α-reduced metabolites in rat hepatocytes, with a Kd of 268 nM[1].
5α-Tetrahydrocorticosterone (1 μM, 16 h) increases TAT and PEPCK mRNA in H4IIE cells[1].
5α-Tetrahydrocorticosterone (1-10000 nM, 7 days) causes concentration-dependent suppression of vessel outgrowth from mouse aortic rings, with an EC50 of 2512 nM[2].
5α-Tetrahydrocorticosterone (3 μM) increases the level of Mcp1 and Per1 and suppresses the expression of Pecam1 in aortic rings[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5α-Tetrahydrocorticosterone Related Antibodies
In Vivo

5α-Tetrahydrocorticosterone (5 mg/kg, i.p., single dose) exhibits glucocorticoid effects in the mice that are bilaterally adrenalectomized[1].
5α-Tetrahydrocorticosterone (25-200 μg, local administration, 28 days) suppresses ear swelling induced by croton-oil in the mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult lean male Zucker rats (6-8 weeks) were bilaterally adrenalectomized[1]
Dosage: 5 mg/kg
Administration: i.p.for a single dose
Result: Remained low plasma corticosterone levels.
Induced a classical negative feedback effect upon the hypothalamic-pituitary-adrenal axis.
Animal Model: Male C57BL/6 mice with a single topical application of croton oil in ear skin[3]
Dosage: 25, 100, 200 μg
Administration: local administration for 28 days
Result: Suppressed ear swelling in mice, with an ED50 of 23 μg.
Did not cause skin thinning, adrenal atrophy, weight loss, thymic involution, or raised insulin levels.
Molecular Weight

350.49

Formula

C21H34O4
CAS No.
SMILES

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5α-Tetrahydrocorticosterone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5α-Tetrahydrocorticosterone600-63-55α-THBGlucocorticoid ReceptorEndogenous MetaboliteDrug MetaboliteHeLa cellsinflammationInhibitorinhibitorinhibit

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