5α-Androstan-3α-ol (Synonyms: 3α,5α-Androstanol)

Cat. No.: HY-W722556: Data Sheet Handling Instructions
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5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms.

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5α-Androstan-3α-ol Chemical Structure

CAS No. : 7657-50-3

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Description	5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms^[1].
Molecular Weight	276.46
Formula	C₁₉H₃₂O
CAS No.	7657-50-3
SMILES	C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Kliewer SA, et al. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 1999 Apr 30;284(5415):757-60. [Content Brief]

5α-Androstan-3α-ol Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5α-Androstan-3α-ol7657-50-33α,5α-AndrostanolGABA ReceptorConstitutive Androstane ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorCARNR1I3Nuclear receptorsDNAGABAInhibitorinhibitorinhibit

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5α-Androstan-3α-ol (Synonyms: 3α,5α-Androstanol)

5α-Androstan-3α-ol Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

5α-Androstan-3α-ol Related Classifications

Molarity Calculator

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