2'-Deoxyguanosine monohydrate-¹³C₅ 

2'-Deoxyguanosine monohydrate-¹³C₅ is the ¹³C-labeled 2'-Deoxyguanosine monohydrate (HY-D0185). 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

283.16

C₅¹³C₅H₈N₅O₅

312693-72-4

O=C1C2=C(N=C(N1)N)N([13C@]3[13C][13C@@]([13C@](O3)[13C]O)O)C=N2.O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ravanat JL, et al. Reaction of singlet oxygen with 2'-deoxyguanosine and DNA. Isolation and characterization of the main oxidation products. Chem Res Toxicol. 1995 Apr-May;8(3):379-88.  [Content Brief]