2. Induced Disease Models Products Cell Cycle/DNA Damage
  3. Cancer Models DNA/RNA Synthesis
  4. Liver Cancer Models
  5. 2-Acetamidofluorene

2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours.

For research use only. We do not sell to patients.

2-Acetamidofluorene Chemical Structure

2-Acetamidofluorene Chemical Structure

CAS No. : 53-96-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

2-Acetamidofluorene Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours[1][2].

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

2-Acetamidofluorene-induced HCC rat liver tissues has hepatic cell degeneration, oval cell proliferation, and inflammatory cell infiltration[1].
2-Acetylaminofluorene can be used to induce hepatocellular carcinoma (HCC) Model[1][2][3].

Induction of Hepatocellular Carcinoma (HCC) Model[1][2][3]
Background
2-Acetamidofluorene exhibits strong damaging effects on DNA.
Specific Mmodeling Methods
Rat: Sprague-Dawley?• 2-mo old?• 140-180 g • 0.05% (w/w) • diet fed • 8 weeks
Note
(2). At the end of the 8 weeks, the living rats are then fed with normal granules.
Modeling Indicators
<Histology analysis: Hepatic cell degeneration, oval cell proliferation, and inflammatory cell infiltration.
Correlated Product(s): Carbon tetrachloride (HY-Y0298)
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

223.28

Formula

C15H13NO
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(NC1=CC2=C(C=C1)C(C=CC=C3)=C3C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (559.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4787 mL 22.3934 mL 44.7868 mL
5 mM 0.8957 mL 4.4787 mL 8.9574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4787 mL 22.3934 mL 44.7868 mL 111.9670 mL
5 mM 0.8957 mL 4.4787 mL 8.9574 mL 22.3934 mL
10 mM 0.4479 mL 2.2393 mL 4.4787 mL 11.1967 mL
15 mM 0.2986 mL 1.4929 mL 2.9858 mL 7.4645 mL
20 mM 0.2239 mL 1.1197 mL 2.2393 mL 5.5984 mL
25 mM 0.1791 mL 0.8957 mL 1.7915 mL 4.4787 mL
30 mM 0.1493 mL 0.7464 mL 1.4929 mL 3.7322 mL
40 mM 0.1120 mL 0.5598 mL 1.1197 mL 2.7992 mL
50 mM 0.0896 mL 0.4479 mL 0.8957 mL 2.2393 mL
60 mM 0.0746 mL 0.3732 mL 0.7464 mL 1.8661 mL
80 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3996 mL
100 mM 0.0448 mL 0.2239 mL 0.4479 mL 1.1197 mL
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2-Acetamidofluorene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Acetamidofluorene53-96-3DNA/RNA SynthesisLiver cancerHCChepatocellular carcinoma2-FAAcarcinogenantumourInhibitorinhibitorinhibit

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