2. Others Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug Derivative ADC Payload Topoisomerase
  4. (1R,9S)-Exatecan

(1R,9S)-Exatecan (DX8951f) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

For research use only. We do not sell to patients.

(1R,9S)-Exatecan

(1R,9S)-Exatecan Chemical Structure

CAS No. : 2231666-57-0

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Other Forms of (1R,9S)-Exatecan:

(1R,9S)-Exatecan Related Antibodies

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Topoisomerase Topo I Topo II

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Description

(1R,9S)-Exatecan (DX8951f) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].

IC50 & Target[1]

Topoisomerase I

 

Molecular Weight

435.45

Formula

C24H22FN3O4
CAS No.
SMILES

N[C@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(1R,9S)-Exatecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R,9S)-Exatecan2231666-57-0(1R,9S)-DX8951fDrug DerivativeADC PayloadTopoisomeraseDrug derivativeADC CytotoxinExatecantopoisomerase ICancerstereoisomerInhibitorinhibitorinhibit

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