2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 14,15-Epoxyeicosatrienoic acid

14,15-Epoxyeicosatrienoic acid  (Synonyms: 14,15-EET)

Cat. No.: HY-113489 Purity: ≥99.0%
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COA
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14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research.

For research use only. We do not sell to patients.

14,15-Epoxyeicosatrienoic acid Chemical Structure

14,15-Epoxyeicosatrienoic acid Chemical Structure

CAS No. : 81276-03-1

Size Price Stock Quantity
Solvent
50 μg (312.04 μM * 500 μL in Ethanol) In-stock

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Customer Review

Based on 1 publication(s) in Google Scholar

14,15-Epoxyeicosatrienoic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

14,15-Epoxyeicosatrienoic acid (0-10 μM) promotes Aβ uptake in primary astrocyte cultures[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

14,15-Epoxyeicosatrienoic acid Related Antibodies
In Vivo

14,15-Epoxyeicosatrienoic acid (0.3 mg/kg i.v.) inhibits platelet aggregation in mouse cerebral arterioles[2].
14,15-Epoxyeicosatrienoic acid (200 ng/ml) infusion into the hippocampus reversed Aβ deposition in the brains of 6-month-old male FAD mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

320.47

Formula

C20H32O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCC/C=C/C/C=C/C/C=C/CC1OC1CCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

Ethanol : 3.2 mg/mL (9.99 mM; Need ultrasonic and warming)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (604 KB)

COA (238 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.1204 mL 15.6021 mL 31.2042 mL 78.0104 mL
5 mM 0.6241 mL 3.1204 mL 6.2408 mL 15.6021 mL
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14,15-Epoxyeicosatrienoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

14,15-Epoxyeicosatrienoic acid81276-03-114,15-EETEndogenous MetaboliteAlzheimer's diseaseastrocytelysosomal biogenesissoluble epoxide hydrolaseInhibitorinhibitorinhibit

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