2. Metabolic Enzyme/Protease Apoptosis
  3. FXR Apoptosis
  4. Tauro-β-muricholic acid

Tauro-β-muricholic acid  (Synonyms: TβMCA)

Cat. No.: HY-N9933 Purity: 99.83%
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Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential.

For research use only. We do not sell to patients.

Tauro-β-muricholic acid

Tauro-β-muricholic acid Chemical Structure

CAS No. : 25696-60-0

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Based on 4 publication(s) in Google Scholar

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Tauro-β-muricholic acid Related Antibodies

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Description

Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

IC50 & Target

40 μM (FXR)[1]
Molecular Weight

515.70

Formula

C26H45NO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@]([C@H]([C@H]([C@]1([H])C[C@@H](CC2)O)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)C
Structure Classification
Initial Source

rat
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (48.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9391 mL 9.6956 mL 19.3911 mL
5 mM 0.3878 mL 1.9391 mL 3.8782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9391 mL 9.6956 mL 19.3911 mL 48.4778 mL
5 mM 0.3878 mL 1.9391 mL 3.8782 mL 9.6956 mL
10 mM 0.1939 mL 0.9696 mL 1.9391 mL 4.8478 mL
15 mM 0.1293 mL 0.6464 mL 1.2927 mL 3.2319 mL
20 mM 0.0970 mL 0.4848 mL 0.9696 mL 2.4239 mL
25 mM 0.0776 mL 0.3878 mL 0.7756 mL 1.9391 mL
30 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.6159 mL
40 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2119 mL
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Tauro-β-muricholic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tauro-β-muricholic acid25696-60-0TβMCAFXRApoptosisNR1H4bile acidantiapoptoticmitochondrial membrane potentialInhibitorinhibitorinhibit

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