2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. SVC-02

SVC-02 is a vasohibin (VASH) inhibitor with an IC50 value of 11 nM. SVC-02 reduces tubulin detyrosination. SVC-02 has the potential for the research of reduce myo-cardial stiffness and improve relaxation in Heart failure with preserved ejection fraction (HFpEF).

For research use only. We do not sell to patients.

SVC-02 Chemical Structure

SVC-02 Chemical Structure

CAS No. : 2911548-33-7

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Based on 1 publication(s) in Google Scholar

SVC-02 Related Antibodies

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Description

SVC-02 is a vasohibin (VASH) inhibitor with an IC50 value of 11 nM. SVC-02 reduces tubulin detyrosination. SVC-02 has the potential for the research of reduce myo-cardial stiffness and improve relaxation in Heart failure with preserved ejection fraction (HFpEF)[1].

Molecular Weight

570.63

Formula

C30H38N2O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC1=CC=C(C[C@H](NC([C@H]2O[C@@H]2C(N[C@@H](CC3=CC=C(OCC)C=C3)C(OCC)=O)=O)=O)C(OCC)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (146.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7524 mL 8.7622 mL 17.5245 mL
5 mM 0.3505 mL 1.7524 mL 3.5049 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7524 mL 8.7622 mL 17.5245 mL 43.8112 mL
5 mM 0.3505 mL 1.7524 mL 3.5049 mL 8.7622 mL
10 mM 0.1752 mL 0.8762 mL 1.7524 mL 4.3811 mL
15 mM 0.1168 mL 0.5841 mL 1.1683 mL 2.9207 mL
20 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1906 mL
25 mM 0.0701 mL 0.3505 mL 0.7010 mL 1.7524 mL
30 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.4604 mL
40 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
50 mM 0.0350 mL 0.1752 mL 0.3505 mL 0.8762 mL
60 mM 0.0292 mL 0.1460 mL 0.2921 mL 0.7302 mL
80 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5476 mL
100 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4381 mL
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SVC-02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SVC-022911548-33-7SVC02SVC 02Microtubule/Tubulinmicrotu-bule networkHFpEFtubulin detyrosinationmyocardiumInhibitorinhibitorinhibit

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