2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. SH-BC-893

SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity.

For research use only. We do not sell to patients.

SH-BC-893 Chemical Structure

SH-BC-893 Chemical Structure

CAS No. : 1841409-92-4

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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

SH-BC-893 Related Antibodies

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Description

SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity[1][2].

Cellular Effect
Cell Line Type Value Description References
FL5.12 IC50
1.8 μM
Compound: 3; SH-BC-893
Inhibition of protein phosphatase 2A in mouse FL5.12 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining based flow cytometric analysis
Inhibition of protein phosphatase 2A in mouse FL5.12 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining based flow cytometric analysis
[PMID: 31383588]
FL5.12 IC50
1.9 μM
Compound: 4
Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis
Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis
[PMID: 27475534]
In Vitro

SH-BC-893 starves cancer cells to death by down-regulating cell surface nutrient transporters and blocking lysosomal trafficking events[1].
SH-BC-893 (5 μM; 3 h) protects from ceramide-induced mitochondrial network fragmentation by disrupting intracellular trafficking[2].
SH-BC-893 (8.935 nM; 3 h) protects from ceramide-induced mitochondrial dysfunction[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SH-BC-893 Related Antibodies

Western Blot Analysis[1]

Cell Line: p53 flox/flox MEFs
Concentration: 5 μM
Incubation Time: 3 h
Result: Blocked palmitate-induced recruitment of DRP1 to mitochondria without affecting DRP1 protein levels.

Immunofluorescence[1]

Cell Line: p53 flox/flox MEFs
Concentration: 5 μM
Incubation Time: 3 h
Result: Blocked palmitate-induced recruitment of DRP1 to mitochondria.
In Vivo

SH-BC-893 (oral; 120 mg/kg; single) robustly and acutely blocks ceramide-induced mitochondrial dysfunction, correcting diet-induced obesity and its metabolic sequelae[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (Male)[1]
Dosage: 120 mg/kg
Administration: Oral; single
Result: Blocked palmitate- and ceramide-induced mitochondrial fission, preserved mitochondrial function, and prevented ER stress.
Normalized mitochondrial morphology in the livers and brains of HFD-fed mice, improved mitochondrial function in white adipose tissue, and corrected aberrant plasma leptin and adiponectin levels.
Restored normal body weight, glucose disposal, and hepatic lipid levels in mice consuming a HFD.
Molecular Weight

325.92

Formula

C19H32ClNO
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC[C@H]1NCC[C@@H]1C2=CC=C(CCCCCCCC)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.03%

SDS (251 KB)

COA (244 KB) HNMR (255 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)
References
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SH-BC-893 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SH-BC-8931841409-92-4Mitochondrial Metabolismoralsphingolipid analogceramide-induced mitochondrial dysfunctiondiet-induced obesityInhibitorinhibitorinhibit

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