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systemic hypertension

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1451
    Imidapril hydrochloride

    TA-6366

    		 Angiotensin-converting Enzyme (ACE) MMP Cardiovascular Disease Metabolic Disease
    Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .
    Imidapril hydrochloride
  • HY-17402
    Nisoldipine
    1 Publications Verification

    BAY-k 5552

    		 Calcium Channel Reactive Oxygen Species (ROS) Infection Cardiovascular Disease Neurological Disease
    Nisoldipine (BAY-k 5552; Sular) is an orally active and blood-brain barrier-penetrating dihydropyridine calcium antagonist, with greater vascular selectivity than other calcium channel antagonists. Nisoldipine inhibits calcium influx and blocks voltage-gated calcium channels. Nisoldipine dilates coronary and systemic arteries. Nisoldipine has antihypertensive and anti-anginal activity. Nisoldipine also displays neuroprotective and antiviral activity .
    Nisoldipine
  • HY-17494
    Timolol

    (S)-L-714,465; MK 950 free base

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .
    Timolol
  • HY-17494A
    Timolol hemihydrate

    (S)-L-714,465 hemihydrate; MK 950 hemihydrate

    		 Adrenergic Receptor Infection Cancer
    Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect .
    Timolol hemihydrate
  • HY-B1660
    Guanadrel sulfate

    		Adrenergic Receptor Cardiovascular Disease
    Guanadrel sulfate is an orally active, potent and postganglionic sympathetic inhibitor. Guanadrel sulfate lowers blood pressure by reducing systemic vascular resistance with little effect on cardiac output. Guanadrel sulfate is promising for research of hypertension .
    Guanadrel sulfate
  • HY-17494S1
    Timolol-d9 maleate

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Timolol-d9 (maleate) is deuterium labeled Timolol. Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .
    Timolol-d9 maleate
  • HY-17494B
    Timolol hemimaleate

    (S)-L-714,465 hemimaleate; MK 950 hemimaleate

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Timolol ((S)-L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topical Timolol hemimaleate is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol hemimaleate can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .
    Timolol hemimaleate
  • HY-17494R
    Timolol (Standard)

    (S)-L-714,465 (Standard); MK 950 free base (Standard)

    		 Reference Standards Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Timolol (Standard) is the analytical standard of Timolol. This product is intended for research and analytical applications. Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .
    Timolol (Standard)
  • HY-B1451A
    Imidapril

    TA-6366 free base

    		 Angiotensin-converting Enzyme (ACE) MMP Cardiovascular Disease Metabolic Disease
    Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .
    Imidapril
  • HY-142698
    SGC agonist 2

    		Guanylate Cyclase Cardiovascular Disease
    SGC agonist 2 is a potent agonist of soluble guanylate cyclase (SGC). Soluble guanylate cyclase is a key signal transduction enzyme in the NO-sGC-cGMP signaling pathway. SGC agonist 2 has the potential for the research of cardiovascular disease (heart failure, pulmonary hypertension, angina, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis) (extracted from patent WO2021219088A1, compound 031) .
    SGC agonist 2
  • HY-B1451R
    Imidapril hydrochloride (Standard)

    		Angiotensin-converting Enzyme (ACE) MMP Cardiovascular Disease Metabolic Disease
    Imidapril (hydrochloride) (Standard) is the analytical standard of Imidapril (hydrochloride). This product is intended for research and analytical applications. Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .
    Imidapril hydrochloride (Standard)
  • HY-15402
    Edonentan

    BMS 207940

    		 Endothelin Receptor Cardiovascular Disease
    Edonentan (BMS 207940) is an antagonist for endothelin receptor (ETA receptor), with a Ki of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model .
    Edonentan
  • HY-109163
    Treprostinil palmitil

    INS-1009

    		 Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease .
    Treprostinil palmitil

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