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ribonuclease-h

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (2) HBV (1) HIV (4) HIV Integrase (1) Reverse Transcriptase (1)
By Research Areas:	Infection (6)

6

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Sennoside A 2 Publications Verification	HIV	Infection
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

β-Thujaplicinol 3-Hydroxy-5-isopropyltropolone	HBV DNA/RNA Synthesis	Infection
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively .

NSC727447	HIV DNA/RNA Synthesis	Infection
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC₅₀s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively .

GSK5750	Reverse Transcriptase HIV	Infection
GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC₅₀ value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism .

2-Hydroxyisoquinoline-1,3(2H,4H)-dione	HIV Integrase	Infection
Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and *HIV-1 reverse transcriptase (RT) ribonuclease H* (RNase H) inhibitor with an IC₅₀** value of 6.32, 5.9 µM, respectively .

CI-39	HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 µM and an CC₅₀ of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

Cat. No.	Compare	Product Name	Species	Source

	RNASEH1 Protein, Human (His) ribonuclease H type II; ribonuclease H1; RNH1; RNase H1	Human	E. coli
	RNASEH1 Protein, Human (His) is the recombinant human-derived RNASEH1, expressed by E. coli , with C-6*His labeled tag. ,

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