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Results for "

pyrimidinone

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100789
    ON1231320
    1 Publications Verification

    		 Apoptosis Polo-like Kinase (PLK) Mitosis Cancer
    ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity .
    ON1231320
  • HY-124703
    Pyrimidinone 8

    		Ferroportin Others
    Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM .
    Pyrimidinone 8
  • HY-154325
    1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4(1H)-pyrimidinone

    		Nucleoside Antimetabolite/Analog Cancer
    1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4(1H)-pyrimidinone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4(1H)-pyrimidinone
  • HY-152603
    2-Amino-1-β-D-arabinofuranosyl-5-methyl-4(1H)-pyrimidinone

    		Nucleoside Antimetabolite/Analog Others
    2-Amino-1-β-D-arabinofuranosyl-5-methyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2-Amino-1-β-D-arabinofuranosyl-5-methyl-4(1H)-pyrimidinone
  • HY-142777
    Lp-PLA2-IN-9

    		Phospholipase Neurological Disease
    Lp-PLA2-IN-9 (compound 17), a tetracyclic pyrimidinone compound, is a potent Lp-PLA2 inhibitor with a pIC50 of 10.1 for rhLp-PLA2. Lp-PLA2-IN-9 has the potential for neurodegenerative related diseases research .
    Lp-PLA2-IN-9
  • HY-142774
    Lp-PLA2-IN-6

    		Phospholipase Neurological Disease
    Lp-PLA2-IN-6 (compound 18), a tetracyclic pyrimidinone compound, is a potent Lp-PLA2 inhibitor with a pIC50 of 10.0 for rhLp-PLA2. Lp-PLA2-IN-6 has the potential for neurodegenerative related diseases research .
    Lp-PLA2-IN-6
  • HY-161836
    α2AR agonist 1

    		Adrenergic Receptor Cardiovascular Disease
    α2AR agonist 1 (compound S6a), a new morpholine-containing pyrimidinone, acts as an agonist of α2-adrenoceptor. α2AR agonist 1 induces a concentration-dependent relaxation on aortic ring pre-contracted with Phenylephrine (HY-B0769; pEC50=6.81). α2AR agonist 1 increases NOx and NO levels in HUVECs .
    α2AR agonist 1
  • HY-152877
    Isocytidine

    		Nucleoside Antimetabolite/Analog Others
    2-Amino-1-β-D-ribofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    Isocytidine
  • HY-152878
    Arabinosylisocytosine

    NSC 529488

    		 Nucleoside Antimetabolite/Analog Others
    2-Amino-1-β-D-arabinofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    Arabinosylisocytosine

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