prostate specific antigen (PSA)

By Targets:	PSMA (3) Androgen Receptor (2) Apoptosis (1) Elastase (1) Histone Methyltransferase (2) Prostaglandin Receptor (2)
By Research Areas:	Cancer (9)
Oligonucleotides:	Aptamers (1)

Targets Recommended: PSMA HuR SNIPERs BMI1 FLT3 CD74 Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate is a prostate specific antigen (PSA) fluorescent substrate. Prostate Specific Antigen Substrate can be used for detect enzymatic activity of PSA .

HY-12759

CARM1-IN-1 3 Publications Verification	Histone Methyltransferase	Cancer
CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC₅₀=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC₅₀ >667 μM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity .

HY-12759A

CARM1-IN-1 hydrochloride 3 Publications Verification	Histone Methyltransferase	Cancer
CARM1-IN-1 (compound 7g) hydrochloride is a highly potent and selective inhibitor of CARM1 (IC₅₀=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC₅₀ >667 μM). CARM1-IN-1 hydrochloride inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 hydrochloride also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity .

HY-N8850

Angelol G	Others	Cancer
Angelol G, a coumarin, can be isolated from Campylotropis hirtella. Angelol G shows inhibitory activity for prostate specific antigen (PSA)IC₅₀ value of 152.1μM. Angelol G can be used for the research of benign prostate hyperplasia (BPH) .

HY-P1813

PSA1 (141-150) PSA-Peptide	Prostaglandin Receptor	Cancer
PSA1 (141-150), a prostate specific antigen 1 peptide, is used in the immunotherapy of cancer experiments .

HY-N8856

Angelol M	Others	Others
Angelol M,isolated from the roots of Angelica gigas Nakai, shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells .

HY-162779

CDD-3290	PSMA Elastase	Others
CDD-3290 (Compound 20) is a prostate-specific antigen (PSA) inhibitor with a K_i value of 216 nM. CDD-3290 also inhibits α-chymotrypsin and elastase .

HY-P99554

Topsalysin PRX-302	PSMA	Cancer
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle .

HY-174391

AR antagonist 15	Androgen Receptor Apoptosis	Cancer
AR antagonist 15 is an orally active androgen receptor (AR) antagonist with the IC₅₀ of 97 nM for AR^T787A. AR antagonist 15 disrupts AR nuclear translocation, hinders AR homodimerization, and suppresses transcription of AR-regulated genes by competitive binding to the ligand binding pocket. AR antagonist 15 can significantly lower the prostate-specific antigen (PSA) level. AR antagonist 15 induces apoptosis by reducing the expression of apoptosis pathway related proteins. AR antagonist 15 can be used for the research of prostate cancer.

HY-403733B

(+)-JJ-450	Androgen Receptor Prostaglandin Receptor	Cancer
(+)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) that inhibits AR nuclear localization and transcriptional activity in the absence of androgen. (+)-JJ-450 is less active than (-)-JJ-450 (HY-403733A) in inhibiting prostate-specific antigen (PSA) expression in LN95 cells, possibly because (+)-JJ-450 targets the ligand binding domain (LBD) of AR. (+)-JJ-450 inhibits the transcriptional activity of AR and its splice variants (e.g., ARv7) by promoting the degradation of unliganded AR in the nucleus and reducing the binding of AR to androgen response elements (AREs). (+)-JJ-450 can be used in castration-resistant prostate cancer (CRPC) studies that are resistant to enzalutamide (MDV3100) (HY-70003) .

Cat. No.	Product Name	Target	Research Area

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate is a prostate specific antigen (PSA) fluorescent substrate. Prostate Specific Antigen Substrate can be used for detect enzymatic activity of PSA .

HY-134113

Z-Gly-Pro-Arg-pNA CBZ-Chromozym TH	Peptides	Others
Z-Gly-Pro-Arg-pNA (z-GPR-pNA) is a photometric substrate in Prostate-Specific Antigen (PSA) activation protease assays. Z-Gly-Pro-Arg-pNA (z-GPR-pNA) can be used for the test of trypsin activity .

HY-P1813

PSA1 (141-150) PSA-Peptide	Prostaglandin Receptor	Cancer
PSA1 (141-150), a prostate specific antigen 1 peptide, is used in the immunotherapy of cancer experiments .

Cat. No.	Product Name	Target	Research Area

HY-P99554

Topsalysin PRX-302	PSMA	Cancer
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8850

Angelol G	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Coumarins Phenylpropanoids Plants	Others
Angelol G, a coumarin, can be isolated from Campylotropis hirtella. Angelol G shows inhibitory activity for prostate specific antigen (PSA)IC₅₀ value of 152.1μM. Angelol G can be used for the research of benign prostate hyperplasia (BPH) .

HY-N8856

Angelol M	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Coumarins Phenylpropanoids Plants	Others
Angelol M,isolated from the roots of Angelica gigas Nakai, shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70266

	Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) 1 Publications Verification rHuprostate-specific antigen/KLK3, His; prostate-specific antigen; PSA; Gamma-Seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APS	Human	HEK293
	Kallikrein-3 (PSA) protein, pivotal in the male reproductive system, hydrolyzes semenogelin-1, a seminal vesicle protein. This enzymatic activity initiates seminal coagulum liquefaction, crucial for sperm mobility and fertility. PSA's cleavage of semenogelin-1 highlights its importance in the complex processes of semen physiology and male reproductive function. Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) is the recombinant human-derived Kallikrein-3/PSA protein, expressed by HEK293 , with C-His labeled tag.

HY-P70606

	Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) prostate-specific antigen; PSA; Gamma-seminoprotein; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APS	Human	HEK293
	Kallikrein-3 (PSA) protein, pivotal in the male reproductive system, hydrolyzes semenogelin-1, a seminal vesicle protein. This enzymatic activity initiates seminal coagulum liquefaction, crucial for sperm mobility and fertility. PSA's cleavage of semenogelin-1 highlights its importance in the complex processes of semen physiology and male reproductive function. Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) is the recombinant human-derived Kallikrein-3/PSA protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P81792

	Prostate Specific Antigen Antibody (YA1537) KLK3; APS; prostate-specific antigen; PSA; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase	WB, IHC-P	Human
	Prostate Specific Antigen Antibody (YA1537) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1537), targeting Prostate Specific Antigen, with a predicted molecular weight of 29 kDa (observed band size: 34 kDa). Prostate Specific Antigen Antibody (YA1537) can be used for WB, IHC-P experiment in human background.

HY-P85338

	Prostate Specific Antigen Antibody (YA5030) KLK3; APS; prostate-specific antigen; PSA; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Prostate Specific Antigen Antibody (YA5030) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PSA. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

HY-P83986

	Prostate Specific Antigen Antibody (YA3683) APS; PSA; hK3; KLK2A1; KLK3	IHC-P, FC, ELISA	Human
	Prostate Specific Antigen Antibody (YA3683) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PSA (KLK3). It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

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Cat. No.	Product Name		Classification

HY-160046

AS2 sodium		Aptamers
AS2 sodium is an ssDNA aptamer (Kd: 0.7 nM) for prostate-specific antigen (PSA). AS2 sodium does not bind non-specifically to the anti-target and has the potential to be used in diagnostic systems for prostate cancer detection .

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prostate specific antigen (PSA)

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