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peptide coupling

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36

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2

Fluorescent Dye

17

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4

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W011412
    TSTU

    		Biochemical Assay Reagents Others
    TSTU is used as a coupling reagent in peptide chemistry. TSTU can convert carboxylic acids into the corresponding N-hydroxysuccinimidyl (NHS) esters. TSTU can be applied to the attachment of labels to peptides, proteins, etc .
    TSTU
  • HY-D0177
    (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

    Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

    		 Biochemical Assay Reagents Others
    (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent and BOP analog. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate promotes the reaction of amino and carboxyl groups to form peptide bonds. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate can be used in the synthesis of peptide compounds
    (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
  • HY-79880
    N,N'-Carbonyldiimidazole

    1,1'-Carbonyldiimidazole

    		 Biochemical Assay Reagents Others
    N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent that can activate hydroxyl groups to form reactive carbonyl groups. N,N'-Carbonyldiimidazole can be used as a coupling agent and a peptide synthesis reagent .
    N,N'-Carbonyldiimidazole
  • HY-Y1703
    HATU

    		Biochemical Assay Reagents Others
    HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds .
    HATU
  • HY-W008558
    Fmoc-N-Me-Leu-OH

    		Amino Acid Derivatives Others
    Fmoc-N-Me-Leu-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction.
    Fmoc-N-Me-Leu-OH
  • HY-Y0912
    HBTU

    N-HBTU

    		 Biochemical Assay Reagents Others
    HBTU is a coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis .
    HBTU
  • HY-Y1666
    2,2′-Dipyridyl disulfide

    		Biochemical Assay Reagents Others
    2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers .
    2,2′-Dipyridyl disulfide
  • HY-148031
    MC-Ala-Ala-Asn-PAB-PNP

    		ADC Linker Others
    MC-Ala-Ala-Asn-PAB-PNP is a peptide, can be used to synthesize specifically activated micromolecular target coupling body .
    MC-Ala-Ala-Asn-PAB-PNP
  • HY-120286
    K-13

    		Drug Intermediate Others
    K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.
    K-13
  • HY-W441014C
    DSPE-PEG-NHS ammonium (MW 40000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-NHS (ammonium) (MW 40000) is one of the most commonly used reactive phospholipids for coupling antibodies, proteins, peptides or other substrates to the surface of liposomes and other lipid PEG nanoparticles .
    DSPE-PEG-NHS ammonium (MW 40000)
  • HY-W441014B
    DSPE-PEG-NHS ammonium (MW 20000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-NHS (ammonium) (MW 20000) is one of the most commonly used reactive phospholipids for coupling antibodies, proteins, peptides or other substrates to the surface of liposomes and other lipid PEG nanoparticles .
    DSPE-PEG-NHS ammonium (MW 20000)
  • HY-W441014A
    DSPE-PEG-NHS ammonium (MW 10000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-NHS (ammonium) (MW 10000) is one of the most commonly used reactive phospholipids for coupling antibodies, proteins, peptides or other substrates to the surface of liposomes and other lipid PEG nanoparticles .
    DSPE-PEG-NHS ammonium (MW 10000)
  • HY-W010986
    Fmoc-N-Me-Phe-OH

    		Drug Intermediate Others
    Fmoc-N-Me-Phe-OH is an N-methylated amino acid that can be used for the synthesis of some active compounds .
    Fmoc-N-Me-Phe-OH
  • HY-174358D
    HOOC-PEG-COOH (MW 10000)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 10000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 10000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 10000)
  • HY-174358C
    HOOC-PEG-COOH (MW 5000)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 5000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 5000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 5000)
  • HY-174358
    HOOC-PEG-COOH (MW 1000)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 1000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 1000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 1000)
  • HY-174358E
    HOOC-PEG-COOH (MW 20000)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 20000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 20000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 20000)
  • HY-174358H
    HOOC-PEG-COOH (MW 40000)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 40000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 40000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 40000)
  • HY-174358A
    HOOC-PEG-COOH (MW 2000)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 2000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 2000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 2000)
  • HY-174358B
    HOOC-PEG-COOH (MW 3400)

    		Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 3400) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 3400) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 3400)
  • HY-W283556
    DO2A-tert-butyl ester

    		Biochemical Assay Reagents Cancer
    DO2A-tert-butyl ester is a bifunctional chelator (BFC) that can be used for the coupling of peptides and radionuclides. DO2A-tert-butyl ester can be used in the development of radionuclide imaging tracers .
    DO2A-tert-butyl ester
  • HY-W008235
    Fmoc-N-Me-Ala-OH

    		Amino Acid Derivatives Drug Intermediate Cancer
    Fmoc-N-Me-Ala-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction. Fmoc-N-Me-Ala-OH is a drug intermediate that can be used to synthesize ML-IAP Lys-covalent inhibitor .
    Fmoc-N-Me-Ala-OH
  • HY-107783
    Sulfo-GMBS

    		Others Cancer
    Sulfo-GMBS is a cross-linking agent widely used in chemical modification and coupling reactions of proteins and peptides. Among the amine-sulfhydryl cross-linkers, Sulfo-GMBS generated the largest number of cross-links and covered most of the cross-links that were identified with AMAS and GMBS .
    Sulfo-GMBS
  • HY-149117
    AF430 NHS ester

    		Fluorescent Dye Others
    AF430 NHS ester is an AF 430 maleimide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF430 NHS ester can be uesd for the labeling of amino-groups in peptides, proteins, and oligonucleotides. To achieve specific coupling of dye labels and biomolecules .
    AF430 NHS ester
  • HY-43869
    Vipivotide tetraxetan Ligand-Linker Conjugate

    PSMA-617 Ligand-Linker Conjugate

    		 ADC Linker Cancer
    Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA) .
    Vipivotide tetraxetan Ligand-Linker Conjugate
  • HY-130282
    Ianthelliformisamine C ditrifluoroacetate

    		Bacterial Infection
    Ianthelliformisamine C ditrifluoroacetate is an antibiotic enhancer with activity against resistant Gram-negative bacteria. Ianthelliformisamine C ditrifluoroacetate has been shown to improve the efficacy of doxycycline against Pseudomonas aeruginosa. Ianthelliformisamine C ditrifluoroacetate was prepared using peptide coupling, resulting in high chemical yields of 27 to 91%. Ianthelliformisamine C ditrifluoroacetate exhibits its mechanism of action by inducing ATP efflux and causing membrane depolarization in bacterial cells.
    Ianthelliformisamine C ditrifluoroacetate
  • HY-P10306
    Cys-LL37

    		Bacterial Infection
    Cys-LL37 is a biomaterial with antimicrobial properties developed by covalently fixing to the surface of titanium. Cys-LL37 uses a flexible hydrophilic polyethylene glycol spacer and selective n-terminal coupling LL37, a surface peptide layer that kills bacteria on contact is formed. Cys-LL37 can be used in research to develop new antimicrobial biomaterials .
    Cys-LL37
  • HY-79880R
    N,N'-Carbonyldiimidazole (Standard)

    1,1'-Carbonyldiimidazole (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    N,N'-Carbonyldiimidazole (Standard) (1,1'-Carbonyldiimidazole (Standard)) is the analytical standard of N,N'-Carbonyldiimidazole (HY-79880). This product is intended for research and analytical applications. N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent that can activate hydroxyl groups to form reactive carbonyl groups. N,N'-Carbonyldiimidazole can be used as a coupling agent and a peptide synthesis reagent .
    N,N'-Carbonyldiimidazole (Standard)
  • HY-174961C
    Fmoc-PEG-Maleimide (MW 5000)

    Fmoc-NH-PEG-Mal (MW 5000)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 5000) (Fmoc-NH-PEG-Mal (MW 5000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 5000)
  • HY-174961B
    Fmoc-PEG-Maleimide (MW 3400)

    Fmoc-NH-PEG-Mal (MW 3400)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 3400) (Fmoc-NH-PEG-Mal (MW 3400)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 3400)
  • HY-174961
    Fmoc-PEG-Maleimide (MW 1000)

    Fmoc-NH-PEG-Mal (MW 1000)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 1000) (Fmoc-NH-PEG-Mal (MW 1000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 1000)
  • HY-118112
    4-N-Maleimidobenzoicacid-NHS

    		Biochemical Assay Reagents Others
    4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
    4-N-Maleimidobenzoicacid-NHS
  • HY-174961A
    Fmoc-PEG-Maleimide (MW 2000)

    Fmoc-NH-PEG-Mal (MW 2000)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 2000) (Fmoc-NH-PEG-Mal (MW 2000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 2000)
  • HY-151782
    H-(Gly)3-Lys(N3)-OH

    		ADC Linker Others
    The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-(Gly)3-Lys(N3)-OH
  • HY-D2747
    BP Fluor 405 acid

    		Fluorescent Dye Others
    BP Fluor 405 acid is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The carboxylic acid of BP Fluor 405 is a reagent of choice for the preparation of custom activated esters that often are not commercially available. Examples of such activated esters include sulfo-NHS, TFP (2,3,5,6-Tetrafluorophenol), and STP (4-Sulfo-2,3,5,6-Tetrafluorophenol, Sodium Salt). Another common application for the non-activated carboxylic acid is peptide modification during solid phase synthesis, which usually requires in-situ activation with peptide coupling regents, e.g. HATU. BP Fluor 405 acid is also often used for control experiments, and for calibration.
    BP Fluor 405 acid
  • HY-100138
    2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

    		Radionuclide-Drug Conjugates (RDCs) ADC Linker Cancer
    2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .
    2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

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