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Results for "

naphthalimide

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Fluorescent Dye

5

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129592
    p-Tolylmaleimide

    		Apoptosis Cancer
    p-Tolylmaleimide (compound 9) is a naphthalimide derivative that has cytotoxic effects on cancer cells. p-Tolylmaleimide can arrest the cell cycle of human acute myeloid leukemia cells K562 in the sub-G0/G1 phase and induce apoptosis .
    p-Tolylmaleimide
  • HY-13620
    Elinafide

    LU 79553

    		 Topoisomerase Cancer
    Elinafide is an anticancer agent with a naphthalimide structure that targets DNA. Elinafide interferes with cell metabolism by inserting a planar ring into the DNA double helix and interacting with enzymes through its side chain.LU-79553 is a DNA-binding topoisomerase II inhibitor. The IC50 value of Elinafide for HT-29 cells is 0.014 μM .
    Elinafide
  • HY-118213
    N-(2-Hydroxyethyl)-1,8-naphthalimide

    		Fluorescent Dye Others
    N-(2-Hydroxyethyl)-1,8-naphthalimide is a fluorescent probe for detecting nucleic acids and their precursors. The fluorescence of N-(2-Hydroxyethyl)-1,8-naphthalimide will be quenched by these molecules.
    N-(2-Hydroxyethyl)-1,8-naphthalimide
  • HY-145082
    4-Sulfo-N-(4-aminobenzyl)-1,8-naphthalimide potassium

    		Drug Derivative Others
    4-Sulfo-N-(4-aminobenzyl)-1,8-naphthalimide potassium is an inactive 1,8-Naphthalimide derivative. 4-Sulfo-N-(4-aminobenzyl)-1,8-naphthalimide potassium can be used as a negative control for the clathrin inhibitor 3-Sulfo-N-benzyl-1,8-naphthalimide, potassium salt .
    4-Sulfo-N-(4-aminobenzyl)-1,8-naphthalimide potassium
  • HY-169437
    Nitro-Naphthalimide-C2-acylamide

    		DNA Alkylator/Crosslinker Cancer
    Nitro-Naphthalimide-C2-acylamide is a DNA intercalator. Nitro-Naphthalimide-C2-acylamide can be used for the synthesis of PROTAC-like Naph-Se-TMZ (HY-169433) .
    Nitro-Naphthalimide-C2-acylamide
  • HY-D1267
    PAO-Nap

    		Apoptosis Cancer
    PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase .
    PAO-Nap
  • HY-155141
    hCYP3A4-IN-1

    		Cytochrome P450 Cancer
    hCYP3A4-IN-1 (compound C6) is a potent, orally active hCYP3A4 inhibitor. hCYP3A4-IN-1 shows the IC50 values of 43.93 nM and 153.00 nM against hCYP3A4 in human liver microsomes (HLMs) and CHO-3A4 stably transfected cell line, respectively. hCYP3A4-IN-1 potently inhibits CYP3A4-catalyzed N-ethyl-1,8-naphthalimide (NEN) hydroxylation in a competitive manner (Ki = 30.00 nM) .
    hCYP3A4-IN-1
  • HY-169438
    NNISC-2

    		DNA Alkylator/Crosslinker Cancer
    NNISC-2 (compound 4) is a DNA intercalator-linker conjugate of Naph-Se-TMZ (HY-169433), which is composed of DNA intercalator (blue part) Nitro-Naphthalimide-C2-acylamide (HY-169437) and a linker (black part) .
    NNISC-2
  • HY-169688
    NA-17

    		MDM-2/p53 Apoptosis Cancer
    NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death .
    NA-17
  • HY-P0009B
    Cetrorelix diacetate

    SB-75 diacetate

    		 GnRH Receptor Neurological Disease Endocrinology
    Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM .
    Cetrorelix diacetate
  • HY-P0009A
    Cetrorelix Acetate
    1 Publications Verification

    SB-75 acetate

    		 GnRH Receptor Neurological Disease Endocrinology
    Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM .
    Cetrorelix Acetate
  • HY-169433
    Naph-Se-TMZ

    		PROTACs HDAC Cancer
    Naph-Se-TMZ is a PROTAC-like HDAC1 degrader. Naph-Se-TMZ can reduce the total HDAC activity in glioma cells and enhance the inhibitory effect of Temozolomide (HY-17364). Naph-Se-TMZ consists of the target protein ligand (red part) Temozolomide (HY-17364), the DNA-targeting intercalator (blue part) Nitro-Naphthalimide-C2-acylamide (HY-169437) and the molecular linker (black part). At the same time, the active control of the target protein ligand is: Temozolomide-amino hydrochloride (HY-169439), and the DNA targeting intercalator + linker is: NNISC-2 (HY-169438) .
    Naph-Se-TMZ
  • HY-131374
    TN14003

    		CXCR Cancer
    TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity .
    TN14003
  • HY-P0171
    Motixafortide
    3 Publications Verification

    BKT140 (4-fluorobenzoyl); BL-8040; TF14016

    		 CXCR Endocrinology Cancer
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM.
    Motixafortide
  • HY-P4452
    PRL 2915

    		Somatostatin Receptor Urotensin Receptor Endocrinology
    PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM .
    PRL 2915

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