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Results for "

mitochondrial uncoupling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mitochondrial Metabolism (17) Mitophagy (1) AMPK (1) Antibiotic (1) Apoptosis (2) Autophagy (1) Bacterial (3) Biochemical Assay Reagents (1) Endogenous Metabolite (1) HIV (1) HSP (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (4) NO Synthase (1) Oxidative Phosphorylation (2) p38 MAPK (1) PKC (1) Potassium Channel (1) RABV (1) Reactive Oxygen Species (ROS) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (2) Metabolic Disease (9)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism Mitophagy

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110284

BAM 15 5+ Cited Publications	Oxidative Phosphorylation Mitochondrial Metabolism	Others
BAM 15 is a mitochondrial protonophore uncoupler. BAM 15 is an oxidative phosphorylation (OXPHOS) uncoupler .

HY-136855

MitoPBN	Endogenous Metabolite	Metabolic Disease
MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC₅₀=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

HY-W032022

1-Hexanol	Biochemical Assay Reagents Mitochondrial Metabolism	Others
1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-134769

OPC-163493	Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease
OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease .

HY-162302

NMY1009	Others	Metabolic Disease
NMY1009 is a lipophilic C8-hydrocarbon chain conjugated analog that links mitochondrial uncouplers via ether linkages. NMY1009 can be released and enter the mitochondrial matrix and intermembrane space, thereby targeting mitochondrial uncoupler to adipose tissue and increasing energy expenditure in brown and white adipose tissue .

HY-168639

AMPK activator 15	Mitochondrial Metabolism AMPK	Metabolic Disease
AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830)-induced lipid deposition in hepatocytes .

HY-176148

ZGL-18	Mitochondrial Metabolism	Metabolic Disease
ZGL-18 is an uncoupling protein 1 (UCP1)-inspired mitochondrial uncoupler. ZGL-18 activates brown adipocytes and reduces mitochondrial membrane potential .

HY-169926

AK-4	Mitochondrial Metabolism	Cancer
AK-4 is a glucose-lowering agent, acting function as a mitochondrial uncoupler .

HY-106472

Tioxaprofen EMD 26644	Bacterial	Infection
Tioxaprofen is a new anti-mycotic drug against Trichophyton mentagrophytes and T. rubrum, and is a potent uncoupling agent of mitochondrial respiration .

HY-137922

SHS4121705	Mitochondrial Metabolism	Metabolic Disease
SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC₅₀ of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH) .

HY-P5315

eNOS pT495 decoy peptide	NO Synthase	Others
eNOS pT495 decoy peptide is a specific decoy peptide to prevent T495 phosphorylation reduced eNOS uncoupling and mitochondrial redistribution. eNOS pT495 decoy peptide is used in ventilator-induced lung injury research .

HY-159881

SHS206	Mitophagy	Metabolic Disease
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that reduces hepatic triglyceride levels. SHS206 exhibits in vivo efficacy in the GAN mouse model and shows inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH) .

HY-170369

SHO1122147	Mitochondrial Metabolism	Metabolic Disease
SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC₅₀=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .

HY-W032022S

1-Hexanol-d13	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₁₃ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S3

1-Hexanol-d5	Mitochondrial Metabolism	Others
1-Hexanol-d₅ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S1

1-Hexanol-d11	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₁₁ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S2

1-Hexanol-d3	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₃ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-117843

Ppc-1	Mitochondrial Metabolism Interleukin Related Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ppc-1 is a *mitochondrial* uncoupler. Ppc-1 enhances *mitochondrial* oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen *Porphyromonas gingivalis*. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities .

HY-153813

Z16078526	p38 MAPK Mitochondrial Metabolism	Others
Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. Z16078526 activates thermogenic gene expression and mitochondrial activity (uncoupled respiration) in mouse brown adipocytes. Z16078526 also stimulates thermogenesis in the mouse .

HY-W032022R

1-Hexanol (Standard)	Mitochondrial Metabolism	Others
1-Hexanol (Standard) is the analytical standard of 1-Hexanol. This product is intended for research and analytical applications. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S4

1-Hexanol-d2	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₂ is deuterated labeled 1-Hexanol (HY-W032022). 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-N6790

Nonactin Ammonium ionophore I	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP	Infection Cancer
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .

HY-109804

CORM-401 5+ Cited Publications	Reactive Oxygen Species (ROS)	Inflammation/Immunology
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis .

HY-18980

Rottlerin Maximum Cited Publications 12 Publications Verification Mallotoxin; NSC 56346; NSC 94525	PKC Autophagy Apoptosis HIV RABV	Infection Cancer
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library	1,274 compounds
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,274 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Mitochondria-Targeted Compound Library

1,274 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 1,274 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Cat. No.	Product Name	Target	Research Area