mGluR7

Isoforms Recommended:	mGluR7

By Targets:	Endogenous Metabolite (4) Isotope-Labeled Compounds (1) mGluR (13) Reference Standards (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Neurological Disease (13)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103111

MMPIP hydrochloride	mGluR	Neurological Disease
MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .

HY-153615

CVN636	mGluR	Neurological Disease
CVN636 is a potent, orally active and selective *mGluR7* allosteric agonist with an EC₅₀ value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability .

HY-103565

AMN082 1 Publications Verification	mGluR	Neurological Disease
AMN082, a selective, orally active, and brain penetrant *mGluR7* agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-103565A

AMN082 free base 1 Publications Verification	mGluR	Neurological Disease
AMN082 free base, a selective, orally active, and brain penetrant *mGluR7* agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-15129

O-Phospho-L-serine 2 Publications Verification L-Serine O-phosphate; L-SOP	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-110190

VU0422288 ML396	mGluR	Neurological Disease
VU0422288 (ML396) is a positive allosteric modulator of group III *mGluRs. VU0422288 inhibits mGluRs* with EC₅₀s of 125 nM, 146 nM, and 108 nM for *mGluR4, mGluR7, and mGluR8*, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice .

HY-158376

mGluR7-IN-1	mGluR	Neurological Disease
mGluR7-IN-1 (compound 2Z) is a *mGluR3* inhibitor .

HY-107503

MMPIP	mGluR	Neurological Disease
MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .

HY-103565R

AMN082 (Standard)	Reference Standards mGluR	Neurological Disease
AMN082 (Standard) is the analytical standard of AMN082. This product is intended for research and analytical applications. AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-103565AR

AMN082 free base (Standard)	Reference Standards mGluR	Neurological Disease
AMN082 (free base) (Standard) is the analytical standard of AMN082 (free base). This product is intended for research and analytical applications. AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-15129S

O-Phospho-L-serine-13C3,15N L-Serine O-phosphate-¹³C₃,¹⁵N; L-SOP-¹³C₃,¹⁵N	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

HY-W751156

O-Phospho-L-serine-13C3 L-Serine O-phosphate-¹³C₃; L-SOP-¹³C₃	Isotope-Labeled Compounds mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine- ¹³C₃ (L-Serine O-phosphate- ¹³C₃) is the ¹³C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

HY-15129R

O-Phospho-L-serine (Standard) L-Serine O-phosphate (Standard); L-SOP (Standard)	Reference Standards mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine (Standard) (L-Serine O-phosphate (Standard)) is the analytical standard of O-Phospho-L-serine (HY-15129). This product is intended for research and analytical applications. O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8). O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.

HY-RS05823

Grm2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Grm2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Grm2 Mouse Pre-designed siRNA Set A Grm2 Mouse Pre-designed siRNA Set A

HY-RS05837

GRM7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GRM7 Human Pre-designed siRNA Set A contains three designed siRNAs for GRM7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GRM7 Human Pre-designed siRNA Set A GRM7 Human Pre-designed siRNA Set A

HY-RS05838

Grm7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Grm7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Grm7 Mouse Pre-designed siRNA Set A Grm7 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15129

O-Phospho-L-serine 2 Publications Verification L-Serine O-phosphate; L-SOP	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	mGluR Endogenous Metabolite
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

Cat. No.	Product Name	Chemical Structure

HY-15129S

O-Phospho-L-serine-13C3,15N
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

HY-W751156

O-Phospho-L-serine-13C3
O-Phospho-L-serine- ¹³C₃ (L-Serine O-phosphate- ¹³C₃) is the ¹³C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

O-Phospho-L-serine-13C3

O-Phospho-L-serine- ¹³C₃ (L-Serine O-phosphate- ¹³C₃) is the ¹³C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84577

	GRM7 Antibody (YA4274) GLUR7; MGLU7; GPRC1G; mGluR7; PPP1R87	ICC/IF, FC, ELISA	Human
	GRM7 Antibody (YA4274) is a mouse-derived and non-conjugated IgG1 antibody, targeting to GRM7. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

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Cat. No.	Product Name		Classification

HY-RS05823

Grm2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Grm2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05837

GRM7 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GRM7 Human Pre-designed siRNA Set A contains three designed siRNAs for GRM7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05838

Grm7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Grm7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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