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Pathways Recommended:	Anti-infection

Results for "

hepatitis B/C infections

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCV (2) Claudin (1) HCV Protease (2) Liposome (1) Ser/Thr Protease (1) Transmembrane Glycoprotein (1) Virus Protease (2)
By Research Areas:	Cancer (1) Infection (7) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Inhibitory Antibodies

Targets Recommended: Hepatitis E Virus (HEV) HCV HBV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15256

Faldaprevir BI 201335	HCV Protease	Infection
Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with K_i values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC₅₀ values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection .

HY-169815

HCV NS5B polymerase-IN-2	Virus Protease HCV	Infection
HCV NS5B polymerase-IN-2 (Compound 298) is a Ns5b polymerase inhibitor. HCV NS5B polymerase-IN-2 is promising for research of hepatitis C virus (HCV) infections .

HY-10467

HCV-796 analog	Virus Protease	Infection
HCV-796 analog is a potent *NS5B* inhibitor that binds to the palm II site. HCV-796 analog is promising for research of hepatitis C (HCV) infections .

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for research on cancer and infection conditions such as gliomas and hepatitis B virus infection .

HY-P991200

OM-7D3-B3	Claudin HCV	Infection
OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (K_d = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection .

HY-176518

ssPalmE-P4-C2	Liposome Ser/Thr Protease	Infection Neurological Disease Metabolic Disease
ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED₅₀ of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research .

HY-15256A

Faldaprevir sodium BI 201335 sodium	HCV Protease	Infection
Faldaprevir sodium is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with K_i values of 2.6 and 2.0 nM, respectively. Faldaprevir sodium inhibits HCV RNA replication, with EC₅₀ values of 6.5 and 3.1 nM, respectively. Faldaprevir sodium has potent antiviral activity against chronic HCV infection .

Cat. No.	Product Name

HY-L101

Anti-Liver Cancer Compound Library	2,412 compounds
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers. Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc. MCE offers a unique collection of 2,412 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Anti-Liver Cancer Compound Library

2,412 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 2,412 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for research on cancer and infection conditions such as gliomas and hepatitis B virus infection .

HY-P991200

OM-7D3-B3	Claudin HCV	Infection
OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (K_d = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection .

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