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Pathways Recommended:	MAPK/ERK Pathway

Results for "

classic pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (2) Endogenous Metabolite (1)
By Research Areas:	Inflammation/Immunology (2)

Inhibitors & Agonists

Screening Libraries

Inhibitory Antibodies

Targets Recommended: Tissue Factor Pathway Inhibitor (TFPI)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990025

Empasiprubart ARGX-117	Complement System	Inflammation/Immunology
Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models .

HY-W371165

C1s-IN-1 trihydrochloride	Complement System	Inflammation/Immunology
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the K_i of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC₅₀ of 85 μM, inhibits the activation of classic pathway with an IC₅₀ of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the K_i of 51.2 μM .

HY-P2991

Galactose 1-phosphate uridylyltransferase	Endogenous Metabolite	Others
Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of galactose to glucose. Galactose-1-phosphate uridylyltransferase absence results in classic galactosemia in humans and can be used for metabolic disease research .

Cat. No.	Product Name

HY-L217

Mouse Metabolite Compound Library	334 compounds
Metabolic abnormalities lead to dysfunction of metabolic pathways and the accumulation or lack of metabolites, which are recognized hallmarks of the disease. The metabolite signature is closely related to the disease phenotype and is very useful for predicting the diagnosis and prognosis of the disease as well as monitoring treatment. Metabolites can be used as disease markers for diagnostic therapy. As the classic model of disease experiment in vivo, mice metabolites also play a role in disease diagnosis and mechanism research. MCE provides 334 mouse metabolites that can be used in disease research.

Mouse Metabolite Compound Library

334 compounds

Metabolic abnormalities lead to dysfunction of metabolic pathways and the accumulation or lack of metabolites, which are recognized hallmarks of the disease. The metabolite signature is closely related to the disease phenotype and is very useful for predicting the diagnosis and prognosis of the disease as well as monitoring treatment. Metabolites can be used as disease markers for diagnostic therapy. As the classic model of disease experiment in vivo, mice metabolites also play a role in disease diagnosis and mechanism research.

MCE provides 334 mouse metabolites that can be used in disease research.

Cat. No.	Product Name	Target	Research Area

HY-P990025

Empasiprubart ARGX-117	Complement System	Inflammation/Immunology
Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models .

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