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basis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (2) Apoptosis (3) Autophagy (2) Bcl-2 Family (2) Biochemical Assay Reagents (16) Caspase (2) Dimethylargininase (DDAH) (1) Endogenous Metabolite (1) FAAH (1) Glycosidase (1) HDAC (1) iGluR (1) Leukotriene Receptor (1) Liposome (1) Lipoxygenase (2) MMP (2) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (2) p38 MAPK (2) PARP (2) Phosphodiesterase (PDE) (1) Reference Standards (2) Sodium Channel (1) Thymidylate Synthase (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)

By Targets:

Akt (2)

Antibiotic (2)

Apoptosis (3)

Autophagy (2)

Bcl-2 Family (2)

Biochemical Assay Reagents (16)

Caspase (2)

Dimethylargininase (DDAH) (1)

Endogenous Metabolite (1)

FAAH (1)

Glycosidase (1)

HDAC (1)

iGluR (1)

Leukotriene Receptor (1)

Liposome (1)

Lipoxygenase (2)

MMP (2)

Nucleoside Antimetabolite/Analog (1)

P-glycoprotein (2)

p38 MAPK (2)

PARP (2)

Phosphodiesterase (PDE) (1)

Reference Standards (2)

Sodium Channel (1)

Thymidylate Synthase (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (3)

Metabolic Disease (2)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W073196

*Gold(Ⅲ) chloride hydrate (48% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)	Biochemical Assay Reagents	Others
Gold(Ⅲ) chloride hydrate (48% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)) can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (48% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W073196A

*Gold(Ⅲ) chloride hydrate (50% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)	Biochemical Assay Reagents	Others
Gold(Ⅲ) chloride hydrate (50% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (50% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W129975

Boric anhydride,99.98% trace metals basis Boron trioxide,99.98% trace metals basis	Biochemical Assay Reagents
Boric anhydride,99.98% trace metals basis (Boron trioxide,99.98% trace metals basis) is a kind of biochemical reagent.

HY-B1817A

Zinc acetate, 99.99% trace metals basis Zinc(II) acetate, 99.99% trace metals basis	Biochemical Assay Reagents	Others
Zinc acetate, 99.99% trace metals basis (Zinc(II) acetate, 99.99% trace metals basis) can be used as an alternative staining agent in SDS electrophoresis and can also affect the permeability of biological membranes.

HY-W116336B

Zinc oxide, 99.99% metals basis	Biochemical Assay Reagents	Others
Zinc oxide, 99.99% metals basis can be used to prepare biomaterials and for sensor research.

HY-ER013B

Sodium carbonate anhydrous, 99.999% trace metals basis Calcined soda 99.999% trace metals basis	Biochemical Assay Reagents	Others
Sodium carbonate anhydrous, 99.999% trace metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-22009A

Strontium chloride,anhydrous grade,99.99% metals basis	Biochemical Assay Reagents	Others
Strontium chloride,anhydrous grade,99.99% metals basis is a biochemical reagent.

HY-W073196B

*Gold(Ⅲ) chloride hydrate (52% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)	Biochemical Assay Reagents	Others
Gold(Ⅲ) chloride hydrate (52% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (52% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-Y0286A

Diammonium carbonate, 99.999% trace metals basis Carbonic acid (diammonium), 99.999% trace metals basis	Biochemical Assay Reagents	Others
Diammonium carbonate, 99.999% trace metals basis is a biochemical reagent and a buffer component .

HY-22009C

Strontium chloride,monohydrate grade,99.99% metals basis	Biochemical Assay Reagents	Others
Strontium chloride,monohydrate grade,99.99% metals basis is a biochemical reagent.

HY-W019976

Cadmium sulfate hydrate,99.995% trace metals basis	Biochemical Assay Reagents
Cadmium sulfate hydrate,99.995% trace metals basis is a kind of biochemical reagent.

HY-Y1220D

Anhydrous potassium carbonate, 99.995% metals basis	Biochemical Assay Reagents	Others
Anhydrous potassium carbonate, 99.995% metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y0449C

Ammonium thiocyanate, 99.99% trace metals basis Ammonium rhodanide, 99.99% trace metals basis	Biochemical Assay Reagents	Others
Ammonium thiocyanate, 99.99% trace metals basis is widely used in titration methods to determine the concentrations of various metal ions (especially iron and silver) by forming distinctly different complexes.

HY-W088074A

Chromium(III)oxide, 99.9% trace metals basis	Biochemical Assay Reagents	Others
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-Y1102A

Copper(II) acetate, 99.99% trace metals basis	Biochemical Assay Reagents	Others
Copper(II) acetate, 99.99% trace metals basis is biochemical assay reagent that can be used a source of copper in inorganic synthesis, an oxidizing agent and as a catalyst in organic synthesis .

HY-Y0537C

Potassium chloride, ≥99.99% trace metals basis Potassium chloride, suitable for the extraction and solubilization of proteins	Biochemical Assay Reagents	Others
Potassium chloride, ≥99.99% trace metals basis is a biochemical assay reagent suitable for protein extraction and solubilization.

HY-139452

PFB-FDGlu	Glycosidase	Others
PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis .

HY-W540600

Thaumatins	Others	Others
Thaumatins is a protein, which can be purified from the fruit of Thaumatococcus daniellii Benth. Thaumatins is 100,000 times sweeter than sucrose on a molar basis .

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .

HY-W718894

(R)-Dihydrolipoic acid	HDAC	Others
(R)-Dihydrolipoic acid is a compound that inhibits histone deacetylase 6 (HDAC6) activity. The structure of its complex with HDAC6 has been resolved. (R)-Dihydrolipoic acid can inhibit HDAC6 through specific interactions, providing a basis for understanding the relationship between HDAC function and oxidative stress.

HY-100359

CL-82198 Maximum Cited Publications 6 Publications Verification	MMP	Inflammation/Immunology Cancer
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs . CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression .

HY-118210

PHOP	FAAH	Metabolic Disease
PHOP is a fatty acid amide hydrolase (FAAH) inhibitor used to assess inhibitory activity in a fluorometric assay. PHOP can determine FAAH activity by measuring the amount of 4-pyridin-1-ylbutyric acid released by the enzyme in rat brain microsomes. PHOP demonstrates potential as a FAAH inhibitor and can directly measure FAAH activity by reversed-phase HPLC and fluorescence detection, providing a basis for the development of new inhibitors.

HY-16478

Trifluridine/tipiracil hydrochloride mixture 1 Publications Verification TAS-102; FTD/TPI	Nucleoside Antimetabolite/Analog Thymidylate Synthase	Cancer
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .

HY-135711

PDE8B-IN-1	Phosphodiesterase (PDE)	Metabolic Disease
PDE8B-IN-1 is a selective inhibitor of phosphodiesterase 8B (PDE8B) with the activity of enhancing insulin secretion. PDE8B-IN-1 showed good efficacy in high-throughput screening and optimized its ligand efficiency through rapid deconstruction. PDE8B-IN-1 showed high target selectivity and good bioavailability in preclinical development, providing a basis for exploring its potential inhibitory use .

HY-128794

PF-05150122	Sodium Channel	Neurological Disease
PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential .

HY-111027

HDAC8-IN-13	Apoptosis	Infection
HDAC8-IN-13 is a novel histone deacetylase 8 (HDAC8) inhibitor with antiparasitic activity. HDAC8-IN-13 can effectively inhibit the acetyl-L-lysine deacetylase activity of schistosomes, affecting the parasite's infectivity. HDAC8-IN-13 can induce apoptosis and cause the death of schistosome cells. Through a specific structural basis design, HDAC8-IN-13 exhibits reduced affinity for human HDACs, thereby enhancing its selectivity .

HY-165604

C14-490	Liposome	Others
C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs). C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F(ab’)₂ fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs) .

HY-W747548

12(S)-HEPE	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.

HY-122046

Amb123203	Endogenous Metabolite	Infection
Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds .

HY-121586

Nafazatrom Bay g 6575	Lipoxygenase	Cardiovascular Disease
Nafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of β-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatrom's cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro .

HY-16728A

Rapastinel acetate GLYX-13 acetate	iGluR	Neurological Disease
Rapastinel acetate (GLYX-13 acetate) is an N-methyl-D-aspartate (NMDA) receptor modulator with long-acting antidepressant activity. Rapastinel acetate exerts its antidepressant effects by enhancing long-term potentiation (LTP) of synaptic transmission. Rapastinel acetate transiently enhances NMDAR-mediated currents in pyramidal neurons in the hippocampus and medial prefrontal cortex by binding to unique sites on the NMDAR complex. Rapastinel acetate significantly enhanced NMDAR-mediated currents at a concentration of 1 μmol/l and significantly reduced the currents at a concentration of 10 μmol/l. The mechanism of action of Rapastinel acetate is related to the reduction of affinity to intracellular calcium inactivation sites, which provides a theoretical basis for enhancing conductance mediated by NMDAR .

HY-114735

Mandelonitrile benzoate	Antibiotic	Infection
Mandelonitrile benzoate is a defensive secretion of millipedes that releases other chemicals during the cyanidation process in addition to hydrocyanic acid (HCN) and benzaldehyde. Several families of millipedes, including Polydesmidae, Paradoxosomatidae, and Euryuridae, have been shown to secrete phenols and guaiaeol, with one Paradoxosomatid also producing ethylbenzoic acid and benzoic acid. In addition, members of the Xystodesmidae family commonly produce three compounds: benzoic acid, mandelonitrile benzoate, and benzoyl cyanide. Benzoyl cyanide has not been previously discovered as a natural product. These additional natural products are discussed as defensive antipredator and antibiotic agents. Benzoyl cyanide appears to have anesthetic properties for some predators. The study provides a preliminary chemotaxonomic basis for distinguishing various taxonomic groups of millipedes.

HY-N3584

Paris saponin VII 3 Publications Verification Chonglou Saponin VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N3584R

Paris saponin VII (Standard) Chonglou Saponin VII (Standard)	Reference Standards Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-16958R

PD 404182 (Standard)	Antibiotic Dimethylargininase (DDAH) Reference Standards	Inflammation/Immunology
Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

Cat. No.	Product Name

HY-L136

Coagulation and Anti-coagulation Compound Library	1,196 compounds
Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation. Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process. MCE supplies a unique collection of 1,196 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Coagulation and Anti-coagulation Compound Library

1,196 compounds

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 1,196 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

*Gold(Ⅲ) chloride hydrate (48% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)	Biochemical Assay Reagents
Gold(Ⅲ) chloride hydrate (48% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)) can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (48% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

*Gold(Ⅲ) chloride hydrate (50% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)	Biochemical Assay Reagents
Gold(Ⅲ) chloride hydrate (50% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (50% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

Boric anhydride,99.98% trace metals basis Boron trioxide,99.98% trace metals basis	Chelators
Boric anhydride,99.98% trace metals basis (Boron trioxide,99.98% trace metals basis) is a kind of biochemical reagent.

Zinc acetate, 99.99% trace metals basis Zinc(II) acetate, 99.99% trace metals basis	Buffer Reagents
Zinc acetate, 99.99% trace metals basis (Zinc(II) acetate, 99.99% trace metals basis) can be used as an alternative staining agent in SDS electrophoresis and can also affect the permeability of biological membranes.

Zinc oxide, 99.99% metals basis	Drug Delivery
Zinc oxide, 99.99% metals basis can be used to prepare biomaterials and for sensor research.

Sodium carbonate anhydrous, 99.999% trace metals basis Calcined soda 99.999% trace metals basis	Buffer Reagents
Sodium carbonate anhydrous, 99.999% trace metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Strontium chloride,anhydrous grade,99.99% metals basis	Cell Assay Reagents
Strontium chloride,anhydrous grade,99.99% metals basis is a biochemical reagent.

*Gold(Ⅲ) chloride hydrate (52% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)	Biochemical Assay Reagents
Gold(Ⅲ) chloride hydrate (52% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (52% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

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