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alpha-smooth

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Galectin (1) P2Y Receptor (1) Phosphodiesterase (PDE) (1) Ras (1) ROCK (1) TGF-β Receptor (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (2)

5

Inhibitors & Agonists

3

Antibodies

Targets Recommended: 5 alpha Reductase IFNAR α-synuclein PGC-1α

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CCG-222740	Ras ROCK	Cancer
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor . CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis .

2-Thio-UTP	P2Y Receptor	Cardiovascular Disease
2-Thio-UTP is a selective P2Y₂ inhibitor with an EC₅₀ value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

Autotaxin-IN-7	Phosphodiesterase (PDE) TGF-β Receptor	Inflammation/Immunology
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC₅₀ = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .

Galectin-3-IN-6	Galectin	Cardiovascular Disease Inflammation/Immunology Cancer
Galectin-3-IN-6 (Compound 12) is an orally active inhibitor of galectin-3 (Gal-3), with an IC₅₀ value of 12 nM and a K_d value of 13 nM for Gal-3. In a mouse model of acute liver injury and fibrosis induced by CCl4, Galectin-3-IN-6 can significantly reduce the levels of fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, showing significant anti-fibrotic activity. Galectin-3-IN-6 can be used in the research of fibrotic diseases, cancer, and cardiovascular diseases .

ALK5-IN-82	TGF-β Receptor	Cardiovascular Disease
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC₅₀ value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .

Cat. No.	Compare	Product Name	Application	Reactivity

	alpha smooth muscle Actin Antibody (YA627) 1 Publications Verification alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-smooth Muscle Actin; α smooth Muscle Actin;	WB, IHC-P, FC, IP	Human, Mouse
	alpha smooth muscle Actin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 42 kDa, targeting to alpha smooth muscle Actin. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse.

	alpha smooth muscle Actin Antibody(YA3468) alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-smooth Muscle Actin; α smooth Muscle Actin;	WB, IHC-P, ICC/IF, FC, mIHC	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 42 kDa, targeting to alpha smooth muscle Actin. It can be used for WB, IF-Cell, IF-Tissue, IHC-P, FC, mIHC assays with tag free, in the background of Human, Mouse,Rat.

	alpha Smooth Muscle Actin Antibody (YA4126) ACTA2; AAT6; ACTSA; ACTA2; α-smooth Muscle Actin; alpha-actin-2; alpha actin 2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey

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