Skp2-Cip/Kip

By Targets:	Akt (1) Apoptosis (4) CD28 (1) CD3 (1) CDK (1) E1/E2/E3 Enzyme (1) Interleukin Related (2) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) Pim (2) Proteasome (2) PTEN (1) ROS Kinase (1) TNF Receptor (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16230

GGTI-2417	ROS Kinase Apoptosis	Cancer
GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27 ^Kip1 at Thr187 and accumulates p27 ^Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis .

HY-16231

GGTI-2418	Apoptosis	Cancer
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC₅₀s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors .

HY-15301

CC0651	E1/E2/E3 Enzyme	Cancer
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC₅₀=1.72 μM) inhibits the ubiquitination of p27 ^Kip1, as confirmed by dose-response analysis.

HY-114712

SJ572403 3 Publications Verification SJ403	CDK	Others
SJ572403 (SJ403) is a p27 ^Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a K_d value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) .

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and *p27Kip1* degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein ^[2].

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 ^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer .

HY-117513

CEP1612	Proteasome Apoptosis	Cancer
CEP1612 is a dipeptidyl proteasome inhibitor with the IC₅₀ of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo ^[2].

HY-N13904

Argyrin A	Proteasome	Cancer
Argyrin A, a cyclical peptide, is a potent antitumoral agent. Argyrin A exerts its effects through a potent inhibition of the proteasome. Argyrin A leads to increased endogenous p27 ^kip1 levels by preventing protein turnover .

HY-P1404

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

HY-N13944

Argyrin F	Apoptosis	Cancer
Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27 ^kip, up-regulated p21 ^waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC) .

HY-19486

UR-1505	Nuclear Factor of activated T Cells (NFAT) CD3 CD28 Interleukin Related	Inflammation/Immunology
UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor. UR-1505 can suppress CD3/CD28 induced T cell proliferation, increase p27 ^KIP levels, and induce G1/S cell cycle arrest. UR-1505 can also inhibit the production of IL-5 and IFN-γ in activated T cells. UR-1505 has immunomodulatory properties and can be used in the study of atopic dermatitis .

Cat. No.	Product Name	Target	Research Area

HY-P1404

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8884

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and *p27Kip1* degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein ^[2].

HY-N13904

Argyrin A	Structural Classification Natural Products Microorganisms Source classification	Proteasome
Argyrin A, a cyclical peptide, is a potent antitumoral agent. Argyrin A exerts its effects through a potent inhibition of the proteasome. Argyrin A leads to increased endogenous p27 ^kip1 levels by preventing protein turnover .

HY-N13944

Argyrin F	Structural Classification Natural Products Microorganisms Source classification	Apoptosis
Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27 ^kip, up-regulated p21 ^waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC) .

Species:	Human (5)
Tag:	His (4) GST (1)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70037

	CDKN1B Protein, Human (His) rHuCyclin-dependent kinase inhibitor 1B/CDKN1B, His; Cyclin-Dependent Kinase Inhibitor 1B; Cyclin-Dependent Kinase Inhibitor p27; p27Kip1; CDKN1B; Kip1	Human	E. coli
	The CDKN1B protein is a key cell cycle regulator that inhibits CDK2 when bound to cyclin A, thereby inhibiting G1 phase progression. It exhibits significant inhibitory effects on cyclin E- and cyclin A-CDK2 complexes. CDKN1B Protein, Human (His) is the recombinant human-derived CDKN1B protein, expressed by E. coli , with N-6*His labeled tag.

HY-P75675

	CIB2 Protein, Human (His) Calcium and integrin-binding family member 2; Kinase-interacting protein 2; Kip2	Human	E. coli
	CIB2 protein: Calcium and integrin-binding protein involved in intracellular calcium regulation, auditory hair cell mechanotransduction, and maintenance of stereocilia bundle morphology. CIB2 Protein, Human (His) is the recombinant human-derived CIB2 protein, expressed by E. coli , with N-His labeled tag.

HY-P75675A

	CIB2 Protein, Human (N-His) Calcium and integrin-binding family member 2; Kinase-interacting protein 2; Kip2	Human	E. coli
	CIB2 protein: Calcium and integrin-binding protein involved in intracellular calcium regulation, auditory hair cell mechanotransduction, and maintenance of stereocilia bundle morphology. CIB2 Protein, Human (N-His) is the recombinant human-derived CIB2, expressed by E. coli, with N-6His labeled tag. The total length of CIB2 Protein, Human (N-His) is 187 a.a.*.

HY-P71583

	LAMTOR1 Protein, Human (His) C11orf59; LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; LTOR1_HUMAN; p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; PDRO; PP7157; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59	Human	E. coli
	The LAMTOR1 protein is an important component of the Ragulator complex and plays dual roles in amino acid sensing and mTORC1 activation. It acts as a guanine nucleotide exchange factor (GEF) for Rag GTPases and mediates their recruitment to the lysosomal membrane. LAMTOR1 Protein, Human (His) is the recombinant human-derived LAMTOR1 protein, expressed by E. coli , with N-His labeled tag.

HY-P700392

	UBAC1 Protein, Human (GST) UBAC1; UBA domain containing 1; UBADC1, ubiquitin associated domain containing 1; ubiquitin-associated domain-containing protein 1; GBDR1; UBA domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; ubiquitin associated domain containing 1; Kip1 ubiquitination-promoting complex protein 2; glialblastoma cell differentiation-related protein 1; putative glialblastoma cell differentiation-related protein; UBADC1; RP11-432J22.3	Human	E. coli
	The UBAC1 protein is a non-catalytic component of the KPC complex and contributes to polyubiquitination, targeting proteins such as CDKN1B and NFKB1. The KPC complex regulates the cell cycle by ubiquitinating and degrading CDKN1B during G1 phase. UBAC1 Protein, Human (GST) is the recombinant human-derived UBAC1 protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80256

	*p27 KIP* 1 Antibody (YA253)** 1 Publications Verification	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	p27 KIP 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to p27 KIP 1. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81749A

	*Phospho-p27 Kip* 1 (Ser10) Antibody (YA1494) (PBS only)** CDKN1B; Kip1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1494), targeting Phospho-p27 Kip 1 (Ser10), with a predicted molecular weight of 22 kDa (observed band size: 27 kDa). Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P86556

	*p27 KIP* 1 Antibody (YA6248)** CDKN1B; Kip1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	p27 KIP 1 Antibody (YA6248) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p27 KIP 1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P81749

	*Phospho-p27 Kip* 1 (Ser10) Antibody (YA1494)** CDKN1B; Kip1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1494), targeting Phospho-p27 Kip 1 (Ser10), with a predicted molecular weight of 22 kDa (observed band size: 27 kDa). Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P85924

	p57kip2 Antibody (YA5616) Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; Kip 2; Kip2; p57; p57 Kip 2; p57Kip2; WBS	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	p57kip2 Antibody (YA5616) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to p57kip2. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.

HY-P85964

	p57kip2 Antibody (YA5656) Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; Kip 2; Kip2; p57; p57 Kip 2; p57Kip2; WBS	IHC-P, WB, ICC/IF, ELISA	Human
	p57kip2 Antibody (YA5656) is a mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to p57kip2. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

HY-P86059

	p57kip2 Antibody (YA5751) Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; Kip 2; Kip2; p57; p57 Kip 2; p57Kip2; WBS	IHC-P, ELISA	Human, Mouse, Rat
	p57kip2 Antibody (YA5751) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to p57kip2. It can be applicated for IHC-P, ELISA assays, in the background of human, mouse, rat.

HY-P84361

	CDKN1C Antibody (YA4058) BWS; WBS; p57; BWCR; Kip2; p57Kip2	WB, IHC-P, ICC/IF, FC, ELISA	Human
	CDKN1C Antibody (YA4058) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CDKN1C. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

HY-P83209

	*p57 Kip2 Antibody (YA2954)* CDKN1C; Kip2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	p57 Kip2 Antibody (YA2954) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2954), targeting p57 Kip2, with a predicted molecular weight of 32 kDa (observed band size: 57 kDa). p57 Kip2 Antibody (YA2954) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P85705

	*P27 Kip1 Antibody (YA5397)*	IHC-P, WB	Human, Mouse, Rat
	P27 Kip1 Antibody (YA5397) is a mouse-derived and non-conjugated monoclonal antibody, targeting to P27 Kip1. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

HY-P85970

	p27Kip1 Antibody (YA5662)	IHC-P, WB, ICC/IF, ELISA	Human
	p27Kip1 Antibody (YA5662) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p27Kip1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

HY-P85310

	p27 Antibody (YA5002) CDKN1B; Kip1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1	WB, ELISA	Human
	p27 Antibody (YA5002) is a mouse-derived and non-conjugated monoclonal antibody, targeting to p27. It can be applicated for WB, ELISA assays, in the background of human.

HY-P85102

	CIB1 Antibody (YA4794) CIB1; CIB; Kip; PRKDCip; Calcium and integrin-binding protein 1; CIB; Calcium- and integrin-binding protein; CIBP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; Kip; SNK-interacting protein 2-28; SIP2-28	WB, IHC-P, ICC/IF, ELISA	Human
	CIB1 Antibody (YA4794) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CIB1. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

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