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Siphonaxanthin

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-165537
    Siphonaxanthin

    		FGFR Apoptosis Bcl-2 Family Caspase Cardiovascular Disease Inflammation/Immunology Cancer
    Siphonaxanthin is a keto-carotenoid with anti-angiogenic activity, which is found in green algae. Siphonaxanthin targets death receptor 5 (DR5) and induces apoptosis in cancer cells. Siphonaxanthin upregulates the expression of DR5, decreases the expression of Bcl-2, and activates caspase-3 in human leukemia HL-60 cells. Siphonaxanthin is an inhibitor of fibroblast growth factor receptor-1 (FGFR-1) signaling transduction in vascular endothelial cells. Siphonaxanthin inhibits the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), as well as the outgrowth of microvessels in the rat aortic ring. Siphonaxanthin can also inhibit the translocation of the high-affinity IgE receptor (FcεRI) to lipid rafts in mast cells, acting as an anti-inflammatory agent. Siphonaxanthin is promising for research of diseases such as cancer, diabetic retinopathy, and rheumatoid arthritis .
    Siphonaxanthin

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