2. Search Result
Search Result
Results for "

SREBP 2

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

3

Natural
Products

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14452
    Fatostatin
    30+ Cited Publications

    125B11

    		 Fatty Acid Synthase (FASN) Cancer
    Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .
    Fatostatin
  • HY-14452A
    Fatostatin hydrobromide
    30+ Cited Publications

    125B11 hydrobromide

    		 Fatty Acid Synthase (FASN) Cancer
    Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .
    Fatostatin hydrobromide
  • HY-W510159
    5-O-Methylembelin

    		PCSK9 Cardiovascular Disease
    5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .
    5-O-Methylembelin
  • HY-111355B
    Cholesteryl sulfate sodium

    		Endogenous Metabolite Metabolic Disease
    Cholesteryl sulfate sodium is an orally available, NPC2-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC50=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation .
    Cholesteryl sulfate sodium
  • HY-RS13758
    SREBF2 Human Pre-designed siRNA Set A

    SREBP2; bHLHd2; SREBP-2

    		 Small Interfering RNA (siRNA) Others

    SREBF2 Human Pre-designed siRNA Set A contains three designed siRNAs for SREBF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SREBF2 Human Pre-designed siRNA Set A
    SREBF2 Human Pre-designed siRNA Set A
  • HY-RS28463
    Srebf2 Rat Pre-designed siRNA Set A

    SREBP-2; SREBP2; Srebf2_retired

    		 Small Interfering RNA (siRNA) Others
    Srebf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Srebf2 Rat Pre-designed siRNA Set A
    Srebf2 Rat Pre-designed siRNA Set A
  • HY-RS21946
    Srebf2 Mouse Pre-designed siRNA Set A

    nuc; lop13; SREBP2; bHLHd2; SREBP-2; SREBP2gc

    		 Small Interfering RNA (siRNA) Others

    Srebf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Srebf2 Mouse Pre-designed siRNA Set A
    Srebf2 Mouse Pre-designed siRNA Set A
  • HY-N10702
    PCSK9-IN-9

    		PCSK9 Cardiovascular Disease
    PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM .
    PCSK9-IN-9

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: