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SIGMAR1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (2) Autophagy (2) mTOR (2) PI3K (2) Reference Standards (1) Sigma Receptor (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0837

Veratramine 1 Publications Verification NSC17821; NSC23880	PI3K Akt mTOR Autophagy Apoptosis	Neurological Disease Metabolic Disease Cancer
Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a *SIGMAR1* modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy ^[1] .

HY-RS12910

Sigmar1 Rat Pre-designed siRNA Set A Oprs1	Small Interfering RNA (siRNA) Sigma Receptor	Others
Sigmar1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sigmar1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sigmar1 Rat Pre-designed siRNA Set A Sigmar1 Rat Pre-designed siRNA Set A

HY-RS12909

Sigmar1 Mouse Pre-designed siRNA Set A Oprs1; Sig1R; sigma1R	Small Interfering RNA (siRNA) Sigma Receptor	Others
Sigmar1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sigmar1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sigmar1 Mouse Pre-designed siRNA Set A Sigmar1 Mouse Pre-designed siRNA Set A

HY-RS12908

SIGMAR1 Human Pre-designed siRNA Set A SRBP; ALS16; DSMA2; HMNR2; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSIGMAR1	Small Interfering RNA (siRNA) Sigma Receptor	Others
SIGMAR1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIGMAR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIGMAR1 Human Pre-designed siRNA Set A SIGMAR1 Human Pre-designed siRNA Set A

HY-N0837R

Veratramine (Standard) NSC17821 (Standard); NSC23880 (Standard)	Reference Standards PI3K Akt mTOR Autophagy Apoptosis	Neurological Disease Metabolic Disease Cancer
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a *SIGMAR1* modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0837

Veratramine 1 Publications Verification NSC17821; NSC23880	Alkaloids Piperidine Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a *SIGMAR1* modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy ^[1] .

HY-N0837R

Veratramine (Standard) NSC17821 (Standard); NSC23880 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification other families Source classification Plants	Reference Standards PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a *SIGMAR1* modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P703280

	SIGMAR1 Protein, Human (sf9) OPRS1; SRBP	Human	Sf9 insect cells
	SIGMAR1 Protein, Human (sf9) is the recombinant human-derived SIGMAR1, expressed by sf9 insect cells , with tag Free labeled tag. ,

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Sigmar1 Rat Pre-designed siRNA Set A Oprs1		siRNAs Rat Pre-designed siRNA Sets
Sigmar1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sigmar1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sigmar1 Mouse Pre-designed siRNA Set A Oprs1; Sig1R; sigma1R		siRNAs Mouse Pre-designed siRNA Sets
Sigmar1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sigmar1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIGMAR1 Human Pre-designed siRNA Set A SRBP; ALS16; DSMA2; HMNR2; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSIGMAR1		siRNAs Human Pre-designed siRNA Sets
SIGMAR1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIGMAR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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