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SHOC2–RAS interaction-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-202699
    SHOC2–RAS interaction-IN-1

    		Ras Apoptosis Cancer
    SHOC2-RAS interaction-IN-1 (compound 6) is a non-covalent competitive inhibitor targeting the interaction between SHOC2 and RAS proteins. SHOC2-RAS interaction-IN-1 has an IC50 of 0.048 μM and a KD of 0.065 μM for NRAS Q61R. SHOC2-RAS interaction-IN-1 can inhibit the activity of the SMP phosphatase complex, leading to increased CRAF S259 phosphorylation levels, thereby blocking the MAPK signaling pathway (such as reducing the levels of pMEK and pERK), inducing tumor cell cycle arrest and apoptosis. SHOC2-RAS interaction-IN-1 can be used for targeted research on malignant tumors such as melanoma and colorectal cancer with NRAS Q61R mutations [1].
    SHOC2–RAS interaction-IN-1

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