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SD-91

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150251
    SD-91

    STAT3 degrader-2

    		 PROTACs STAT Cancer
    SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .
    SD-91
  • HY-176506
    Deoxy-thalidomide-alkyne-hexanoic acid

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Deoxy-thalidomide-alkyne-hexanoic acid is a E3 ligase ligand-linker conjugate that can be used for synthesis of PROTAC degrader SD-91 (HY-150251) .
    Deoxy-thalidomide-alkyne-hexanoic acid

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