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Poly(ADP-ribose) Glycohydrolase (PARG)

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By Targets:	Poly(ADP-ribose) Glycohydrolase (PARG) (12) Apoptosis (1) Bacterial (3) Endogenous Metabolite (1) Histamine Receptor (1) Reference Standards (2)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (3) Inflammation/Immunology (1)

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Targets Recommended: Poly(ADP-ribose) Glycohydrolase (PARG) PARP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108360

PDD 00017273 Maximum Cited Publications 15 Publications Verification	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC₅₀ of 26 nM, and a K_D of 1.45 nM .

HY-115666

COH34 analog 1	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
COH34 analog 1, a metabolite, is an oxidized analog of COH34. COH34 is a potent poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

HY-133530

PDD00017238	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
PDD00017238 is a potent inhibitor of **Poly(ADP-ribose) Glycohydrolase (PARG), with EC₅₀** values of 40 nM and 55 nM in biochemical assay and cell POM, respectively .

HY-134354A

pNP-ADPr disodium ADP-ribose-pNP disodium	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
pNP-ADPr disodium is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr disodium can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .

HY-128760

COH34 1 Publications Verification	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
COH34 is a potent and specific **poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC₅₀** of 0.37 nM. COH34 binds to the catalytic domain of PARG (K_d=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors .

HY-135846

PDD00031705 1 Publications Verification	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD00031705 is a benzimidazolone core cell-inactive inhibitor of **Poly (ADP-ribose) glycohydrolase (PARG)** .

HY-B2174

Ethacridine lactate 2 Publications Verification Acrinol	Bacterial	Infection
Ethacridine lactate (Acrinol) is a widely used antiseptic and abortifacient. Ethacridine lactate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

HY-B0889

Ethacridine lactate monohydrate 2 Publications Verification Acrinol monohydrate	Bacterial	Infection
Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

HY-134354

pNP-ADPr ADP-ribose-pNP	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
pNP-ADPr is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .

HY-122041

Ethacridine	Apoptosis Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
Ethacridine is a **poly(ADP-ribose) glycohydrolase (PARG) inhibitor and an activator of the transcriptional coactivator. Ethacridine induces thyroid cancer cells apoptosis** and promotes differentiation in thyroid follicular cells .

HY-137924

JA2131	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
JA2131 is a small molecular inhibitor of **Poly(ADP-ribose) Glycohydrolase (PARG) (IC₅₀**=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death .

HY-133531

PDD00017272	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD00017272 is an inhibitor of **poly(ADP-ribose) glycohydrolase (PARG) (EC₅₀=4.8 nM) and an activator of PARP1/2*. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr* on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC₅₀ of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive .

HY-B0889R

Ethacridine lactate monohydrate (Standard) Acrinol monohydrate (Standard)	Reference Standards Bacterial	Infection
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

HY-112175R

N-Acetylhistamine (Standard) N-Omega-acetylhistamine (Standard)	Reference Standards Histamine Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

HY-146248

TFMU-ADPr	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

HY-146248A

TFMU-ADPr triethylamine	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
TFMU-ADPr triethylamine is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr triethylamine can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr triethylamine has excellent reactivity, generality, stability, and usability. TFMU-ADPr triethylamine is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

Cat. No.	Product Name	Type

HY-146248

TFMU-ADPr	Chromogenic Substrates
TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

TFMU-ADPr

Chromogenic Substrates

TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

N-Acetylhistamine (Standard) N-Omega-acetylhistamine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Histamine Receptor Endogenous Metabolite
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

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