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Results for "

PH1

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

8

Fluorescent Dye

4

Biochemical Assay Reagents

2

Natural
Products

1

Isotope-Labeled Compounds

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-132613
    Lumasiran sodium

    		Small Interfering RNA (siRNA) Metabolic Disease
    Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) [1] .
    Lumasiran sodium
  • HY-132588
    Lumasiran

    ALN-G01

    		 Small Interfering RNA (siRNA) Metabolic Disease
    Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) [1] .
    Lumasiran
  • HY-113377A
    L-Glyceric acid sodium

    		Endogenous Metabolite Metabolic Disease
    L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2 [1] .
    L-Glyceric acid sodium
  • HY-155386
    Peroxynitrite sodium

    		Biochemical Assay Reagents Others
    Peroxynitrite sodium is a highly reactive nitroxide species that can decompose at physiological pH .
    Peroxynitrite sodium
  • HY-D0265
    Thymolphthalein

    		Fluorescent Dye Others
    Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH .
    Thymolphthalein
  • HY-D0015
    Cresol red, 97%

    		Biochemical Assay Reagents Others
    Cresol red, 97% is an anionic dye used as a pH indicator (pH 1.8 orange - pH 2.0 yellow, pH 7.0 yellow - pH 8.8 purple).
    Cresol red, 97%
  • HY-D1094
    Carboxy-SNARF 1 (5/6-mixture)

    SNARF 1

    		 Fluorescent Dye Others
    Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement pH .
    Carboxy-SNARF 1 (5/6-mixture)
  • HY-148610
    LDH-IN-2

    		Others Metabolic Disease
    LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1) [1].
    LDH-IN-2
  • HY-113377
    L-Glyceric acid

    		Endogenous Metabolite Metabolic Disease
    L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2 [1] .
    L-Glyceric acid
  • HY-W176012
    Glycolate oxidase-IN-1

    		Others Metabolic Disease
    Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) [1].
    Glycolate oxidase-IN-1
  • HY-D1694
    LysoTracker Yellow HCK 123

    		Fluorescent Dye Others
    LysoTracker Yellow HCK 123 is a potent yellow membrane-permeable fluorescent probe. LysoTracker Yellow HCK 123 is a weakly basic amine that selectively accumulates in cellular compartments with low luminal pH .
    LysoTracker Yellow HCK 123
  • HY-D1093
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture)

    		Fluorescent Dye Others
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture)
  • HY-D0219A
    Thymol Blue sodium

    		Fluorescent Dye Others
    Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 [1].
    Thymol Blue sodium
  • HY-D0877
    TAPS

    		Biochemical Assay Reagents Others
    TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .
    TAPS
  • HY-167545
    1-Palmitoyl-2-oleoylphosphatidylethanolamine

    POPE

    		 Liposome Biochemical Assay Reagents Others
    1-Palmitoyl-2-oleoylphosphatidylethanolamine (POPE) is a PE-based synthetic phospholipid that can intercalate with other amphiphilic molecules to form stable bilayers at physiological pH. 1-Palmitoyl-2-oleoylphosphatidylethanolamine can be used in drug delivery research [1].
    1-Palmitoyl-2-oleoylphosphatidylethanolamine
  • HY-145576
    2-Amino-8-oxononanoic acid

    		Fluorescent Dye Others
    2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
    2-Amino-8-oxononanoic acid
  • HY-145413
    BRD2889

    		Glutathione S-transferase Cancer
    BRD2889 is an analog of the alkaloid piperlongumine. BRD2889 is a robust modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) . BRD2889 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BRD2889
  • HY-128369
    Acid Yellow 36

    Metanil Yellow

    		 Cytochrome P450 Others
    Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes [1] .
    Acid Yellow 36
  • HY-145576B
    2-Amino-8-oxononanoic acid hydrochloride

    		Fluorescent Dye Others
    2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
    2-Amino-8-oxononanoic acid hydrochloride
  • HY-W411215
    1,4-Diacetoxy-2,3-dicyanobenzene

    		Fluorescent Dye Others
    1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .
    1,4-Diacetoxy-2,3-dicyanobenzene
  • HY-14818
    Laninamivir
    4 Publications Verification

    R 125489

    		 Influenza Virus Infection
    Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1].
    Laninamivir
  • HY-14818R
    Laninamivir (Standard)

    		Influenza Virus Infection
    Laninamivir (Standard) is the analytical standard of Laninamivir. This product is intended for research and analytical applications. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1].
    Laninamivir (Standard)
  • HY-14818S1
    Laninamivir-13C,15N2

    R 125489-13C,15N2

    		 Isotope-Labeled Compounds Influenza Virus Infection
    Laninamivir- 13C, 15N2 (R 125489- 13C, 15N2) is 13C and 15N labeled Laninamivir. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1].
    Laninamivir-13C,15N2
  • HY-D0219
    Thymol blue

    ThymolsulPHonePHthalein

    		 Fluorescent Dye Others
    Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI - form) under acidic conditions and blue (I 2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].
    Thymol blue
  • HY-137873
    4-Methylumbelliferyl-α-D-Glucopyranoside

    4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside; 4-MU-α-D-Glucopyranoside

    		 Fluorescent Dye Glycosidase Others
    4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose) is a fluorescent substrate for α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-α-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase activity in infant blood spot samples.
    4-Methylumbelliferyl-α-D-Glucopyranoside

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