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Results for "

NKA

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

4

Peptides

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P0197A
    Neurokinin A TFA
    3 Publications Verification

    Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA

    		 Neurokinin Receptor Neurological Disease Endocrinology
    Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
    Neurokinin A TFA
  • HY-P3849
    [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)

    LMN-NKA

    		 Neurokinin Receptor Neurological Disease
    [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues .
    [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
  • HY-W013375
    Thiorphan
    1 Publications Verification

    		 Neprilysin Neurological Disease
    Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .
    Thiorphan
  • HY-P1279
    [Lys5,MeLeu9,Nle10]-NKA(4-10)

    		Neurokinin Receptor Inflammation/Immunology
    [Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM .
    [Lys5,MeLeu9,Nle10]-NKA(4-10)
  • HY-P1279A
    [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA

    		Neurokinin Receptor Neurological Disease
    [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM .
    [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA
  • HY-117053
    ZM 253270

    		Neurokinin Receptor Neurological Disease
    ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [ 3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [ 3H]NKA to cloned human NK-2R .
    ZM 253270

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