NEDD4

By Targets:	Akt (2) E1/E2/E3 Enzyme (3) EGFR (1) Endogenous Metabolite (1) ERK (1) MyD88 (1) PROTACs (1) Ras (1) Small Interfering RNA (siRNA) (6) α-synuclein (1)
By Research Areas:	Cancer (5) Infection (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162809

XMU-MP-9	Ras	Cancer
XMU-MP-9 is a bifunctional compound that binds to the C2 domain of *Nedd4-1* and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between *Nedd4-1* and K-Ras, induces conformational changes in the *Nedd4-1/K-Ras* complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer .

HY-N10159

1-Benzyl-I3C	Others	Cancer
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .

HY-110174

NAB2	α-synuclein	Neurological Disease
NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase *Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4*-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease .

HY-RS23685

Nedd4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nedd4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nedd4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nedd4 Rat Pre-designed siRNA Set A Nedd4 Rat Pre-designed siRNA Set A

HY-RS17232

Nedd4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nedd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nedd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nedd4 Mouse Pre-designed siRNA Set A Nedd4 Mouse Pre-designed siRNA Set A

HY-RS09179

NEDD4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEDD4 Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEDD4 Human Pre-designed siRNA Set A NEDD4 Human Pre-designed siRNA Set A

HY-174375

NEDD4-IN-1	Others	Cancer
NEDD4-IN-1 (Compound 32) is a potent inhibitor of *NEDD4* (IC₅₀ = 0.12 μM). NEDD4-IN-1 shows significant and comparable antiproliferative activity in H292 cell line. NEDD4-IN-1 demonstrates high plasma protein binding and medium-to-high in vitro clearance in both human and mouse models. NEDD4-IN-1 shows superior stability in mouse plasma. NEDD4-IN-1 has excellent potency, selectivity, and favourable in vitro ADME properties. NEDD4-IN-1 exhibits a systemic plasma clearance exceeding the hepatic blood flow in mouse model. NEDD4-IN-1 can be studied in anticancer research .

HY-RS17116

Nedd4l Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nedd4l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nedd4l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nedd4l Mouse Pre-designed siRNA Set A Nedd4l Mouse Pre-designed siRNA Set A

HY-RS09180

NEDD4L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEDD4L Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD4L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEDD4L Human Pre-designed siRNA Set A NEDD4L Human Pre-designed siRNA Set A

HY-RS23561

Nedd4l Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nedd4l Rat Pre-designed siRNA Set A contains three designed siRNAs for Nedd4l gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nedd4l Rat Pre-designed siRNA Set A Nedd4l Rat Pre-designed siRNA Set A

HY-110204

Heclin 2 Publications Verification	E1/E2/E3 Enzyme Akt MyD88	Others
Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC₅₀ values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer .

HY-153178

HECT E3-IN-1	E1/E2/E3 Enzyme	Others
HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1 .

HY-122046

Amb123203	Endogenous Metabolite	Infection
Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds .

HY-174415

ZSH-2117	PROTACs EGFR Akt ERK	Cancer
ZSH-2117 is a covalent and selective EGFR PROTAC degrader with a DC₅₀ of 45 nM in Ba/F3-EGFR ^{L858R/T790M/C797S} cells. ZSH-2117 significantly inhibits cell proliferation and reduces the downstream EGFR signaling proteins level of AKT and ERK. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFR ^{L858R/T790M/C797S} xenograft mice model . Pink: EGFR ligand (HY-175162); Blue: NEDD4 ligase ligand (HY-175159); Black: linker

HY-134417

NSC2805 1 Publications Verification	E1/E2/E3 Enzyme	Cancer
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC₅₀ of 0.38 μM. NSC2805 can be used for the research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10159

1-Benzyl-I3C	Structural Classification Natural Products Brassica oleracea L. Source classification Plants Brassicaceae	Others
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .

Species:	Human (5)
Tag:	His (3) Tag Free (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P701595

	NEDD4L Protein, Human NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; NEDD4-2	Human	E. coli
	The NEDD4L protein is an E3 ubiquitin protein ligase that regulates multiple signaling pathways, including autophagy, innate immunity, and DNA repair. NEDD4L Protein, Human is the recombinant human-derived NEDD4L protein, expressed by E. coli , with tag free.

HY-P701596

	NEDD4L Protein, Human (His) NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; NEDD4-2	Human	E. coli
	The NEDD4L protein is an E3 ubiquitin protein ligase that regulates multiple signaling pathways, including autophagy, innate immunity, and DNA repair. NEDD4L Protein, Human (His) is the recombinant human-derived NEDD4L protein, expressed by E. coli , with N-6*His labeled tag.

HY-P77507

	WWP2 Protein, Human (sf9, His-GST) NEDD4-like E3 ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; AIP2; WWP2	Human	Sf9 insect cells
	The WWP2 protein is an E3 ubiquitin protein ligase that coordinates multiple ubiquitination events, including “Lys-63”-linked polyubiquitination of POU5F1, targeting it for proteasomal degradation in embryonic stem cells (ESCs). WWP2 also ubiquitinates EGR2, inhibits activation-induced cell death in T cells, and targets SLC11A2, which is enhanced by NDFIP1 and NDFIP2. WWP2 Protein, Human (sf9, His-GST) is the recombinant human-derived WWP2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P703613

	WWP1 Protein, Human (Active, His) NEDD4-like E3 ubiquitin-protein ligase WWP1; Atrophin-1-interacting protein 5; AIP5; HECT-type E3 ubiquitin transferase WWP1; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1; WWP1; Homo sapiens; Human; AIP5; Transferase; 2.3.2.26	Human	E. coli
	WWP1 Protein, Human (Active, His) is the recombinant human-derived WWP1, expressed by E. coli , with His labeled tag. ,

HY-P703614

	WWP1 Protein, Human (Active) NEDD4-like E3 ubiquitin-protein ligase WWP1; Atrophin-1-interacting protein 5; AIP5; HECT-type E3 ubiquitin transferase WWP1; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1; WWP1; Homo sapiens; Human; AIP5; Transferase; 2.3.2.26	Human	E. coli
	WWP1 Protein, Human (Active) is the recombinant human-derived WWP1, expressed by E. coli , with tag Free labeled tag. ,

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82765

	NEDD4 Antibody (YA2510) RPF1; NEDD4-1	WB, IP	Human, Mouse, Rat
	NEDD4 Antibody (YA2510) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2510), targeting NEDD4, with a predicted molecular weight of 149 kDa (observed band size: 115 kDa). NEDD4 Antibody (YA2510) can be used for WB, IP experiment in human, mouse, rat background.

HY-P86985

	NEDD4L Antibody (YA6678) E3 ubiquitin protein ligase NEDD4 like protein antibody; E3 ubiquitin-protein ligase NEDD4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; NEDD4 2 antibody; NEDD4-2 antibody; NEDD4 2c antibody; NEDD4-2 antibody; NEDD4-2a antibody; NEDD4.2 antibody; E3 ubiquitin protein ligase NEDD4 like protein antibody; E3 ubiquitin-protein ligase NEDD4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; NEDD4 2 antibody; NEDD4-2 antibody; NEDD4 2c antibody; NEDD4-2 antibody; NEDD4-2a antibody; NEDD4.2 antibody; NEDD4b antibody; NEDD4L antibody; NEDD4La antibody; NEDD4Lb antibody; NEDD4Lc antibody; NEDD4Ld antibody; NEDD4Le antibody; NEDD4Lf antibody; NEDD4Lg antibody; NEDD4Lh antibody; NEDL3 antibody; Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody; Neural precursor cell expressed, developmentally down regulated 4 like antibody; RSP5 antibody; Ubiquitin protein ligase Rsp5 antibody	WB, IP	Human, Mouse, Rat