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Menin–KMT2A-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-170832
    Menin–KMT2A-IN-1

    		Epigenetic Reader Domain Potassium Channel Cancer
    Menin–KMT2A-IN-1 (Compound 20) is the inhibitor for menin–KMT2A that binds to menin with an IC50 of 8 nM, and inhibits the interaction between menin and lysine methyltransferase 2A (KMT2A). Menin–KMT2A-IN-1 inhibits hERG with an IC50 of 65 μM. Menin–KMT2A-IN-1 inhibits cell MV4-11 with an IC50 of 74 nM. Menin–KMT2A-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mouse with an orally bioavailability of 74% .
    Menin–KMT2A-IN-1

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