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Results for "

Mechanism-based inhibitor

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Screening Libraries

1

Peptides

1

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100873
    PF-1355
    2 Publications Verification

    PF-06281355

    		 Glutathione Peroxidase Cardiovascular Disease
    PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.
    PF-1355
  • HY-116073
    L-Penicillamine

    		Biochemical Assay Reagents Metabolic Disease
    L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .
    L-Penicillamine
  • HY-120986
    (S)-Bromoenol lactone

    (S)-BEL; (S,E)-Bromoenol lactone

    		 Phospholipase Inflammation/Immunology
    (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM .
    (S)-Bromoenol lactone
  • HY-117068
    (R)-Bromoenol lactone

    (R,E)-Bromoenol lactone

    		 Phospholipase Others
    (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM .
    (R)-Bromoenol lactone
  • HY-125775
    12(S)​-​Hydroxy-​16-​heptadecynoic acid

    (12S)-12-Hydroxy-15-hexadecynoic acid

    		 Prostaglandin Receptor Endocrinology
    12(S)-Hydroxy-16-heptadecynoic acid ((12S)-12-Hydroxy-15-hexadecynoic acid) is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM.
    12(S)​-​Hydroxy-​16-​heptadecynoic acid
  • HY-117068S
    (R)-Bromoenol lactone-d7

    (R,E)-Bromoenol lactone-d7

    		 Isotope-Labeled Compounds Phospholipase Others
    (R)-Bromoenol lactone-d7 ((R,E)-Bromoenol lactone-d7) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM .
    (R)-Bromoenol lactone-d7
  • HY-115824
    7ETMC

    		Cytochrome P450 Others
    7ETMC is a cytochrome P450 inhibitor with selective inhibition of human cytochrome P450s 1A1 and 1A2. 7ETMC has inhibitory effects on P450s 1A1 and 1A2 with IC?? values of 0.46μM and 0.50μM, respectively, within the first six minutes, and has no inhibitory activity against P450s 2A6 and 2B1. Except for 7-ethynyl-3-methyl-4-phenylcoumarin, the remaining inhibitors show mechanism-based inhibition of P450s 1A1 and 1A2.
    7ETMC
  • HY-147691
    MPO-IN-5

    		Glutathione Peroxidase Potassium Channel Inflammation/Immunology
    MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M −1s −1 .
    MPO-IN-5

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