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Isoforms Recommended: mGluR4
Results for "

MGLUR 4

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

4

Natural
Products

2

Isotope-Labeled Compounds

1

Click Chemistry

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18654
    ADX88178
    1 Publications Verification

    mGluR Neurological Disease
    ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.
    ADX88178
  • HY-14417

    mGluR Neurological Disease
    VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD) .
    VU0155041
  • HY-14418

    ML-128

    mGluR Neurological Disease
    VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research .
    VU0361737
  • HY-119078

    mGluR Neurological Disease
    VU0080241 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM .
    VU0080241
  • HY-RS05830

    MGLUR4

    Small Interfering RNA (siRNA) Others

    Grm4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Grm4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Grm4 Rat Pre-designed siRNA Set A
    Grm4 Rat Pre-designed siRNA Set A
  • HY-RS05829

    Gprc1d; MGLUR4

    Small Interfering RNA (siRNA) Others

    Grm4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Grm4 Mouse Pre-designed siRNA Set A
    Grm4 Mouse Pre-designed siRNA Set A
  • HY-RS05828

    mGlu4; GPRC1D; MGLUR4

    Small Interfering RNA (siRNA) Others

    GRM4 Human Pre-designed siRNA Set A contains three designed siRNAs for GRM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GRM4 Human Pre-designed siRNA Set A
    GRM4 Human Pre-designed siRNA Set A
  • HY-121623

    Others Others
    VU0359516 is a compound that modulates mGluR4 activity, obtained through structure-activity relationship analysis of mGluR4 positive allosteric modulators, with improved potency and efficacy, as well as selectivity for mGluR4.
    VU0359516
  • HY-167899

    mGluR Neurological Disease
    PXT-012253 is a positron emission tomography (PET) ligand for mGluR4, as it binds to an allosteric site on mGluR4. PXT-012253 can be utilized in researches related to Parkinson's disease and levodopa-induced dyskinesia .
    PXT-012253
  • HY-14417B

    mGluR Neurological Disease
    VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD) .
    VU0155041 sodium
  • HY-15129
    O-Phospho-L-serine
    2 Publications Verification

    L-Serine O-phosphate; L-SOP

    mGluR Endogenous Metabolite Neurological Disease
    O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .
    O-Phospho-L-serine
  • HY-100804

    mGluR Endogenous Metabolite Neurological Disease
    L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .
    L-Cysteinesulfinic acid
  • HY-W017230

    mGluR Endogenous Metabolite Neurological Disease
    L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .
    L-Cysteinesulfinic acid monohydrate
  • HY-19434A

    iGluR mGluR Neurological Disease
    cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively .
    cis-ACPD
  • HY-14417A

    mGluR Neurological Disease
    (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.
    (1R,2S)-VU0155041
  • HY-108703

    PXT002331

    mGluR Neurological Disease
    Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM . Antiparkinsonian effect .
    Foliglurax
  • HY-100804R

    Reference Standards mGluR Endogenous Metabolite Neurological Disease
    L-Cysteinesulfinic acid (Standard) is the analytical standard of L-Cysteinesulfinic acid. This product is intended for research and analytical applications. L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .
    L-Cysteinesulfinic acid (Standard)
  • HY-110190

    ML396

    mGluR Neurological Disease
    VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice .
    VU0422288
  • HY-111332

    mGluR Others
    (E)-PHCCC is a positive allosteric modulator (PAM) for mGluR4, that enhances the activity of the receptor's endogenous ligand (glutamate), and exhibits activity in the calcium mobilization assay in CHO cells with an EC50 of 3.2 μM .
    (E)-PHCCC
  • HY-108703A

    PXT002331 (monohydrochloride)

    mGluR Neurological Disease
    Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM . Antiparkinsonian effect .
    Foliglurax monohydrochloride
  • HY-15129S

    L-Serine O-phosphate-13C3,15N; L-SOP-13C3,15N

    mGluR Endogenous Metabolite Neurological Disease
    O-Phospho-L-serine- 13C3, 15N is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .
    O-Phospho-L-serine-13C3,15N
  • HY-118022

    mGluR Neurological Disease
    VU0361747 is a potent and selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM). VU0361737 has neuroprotective effect. VU0361737 significantly reverses Amphetamine-induced hyperlocomotion in vivo .
    VU0361747
  • HY-W751156

    L-Serine O-phosphate-13C3; L-SOP-13C3

    Isotope-Labeled Compounds mGluR Endogenous Metabolite Neurological Disease
    O-Phospho-L-serine- 13C3 (L-Serine O-phosphate- 13C3) is the 13C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .
    O-Phospho-L-serine-13C3
  • HY-15129R

    L-Serine O-phosphate (Standard); L-SOP (Standard)

    Reference Standards mGluR Endogenous Metabolite Neurological Disease
    O-Phospho-L-serine (Standard) (L-Serine O-phosphate (Standard)) is the analytical standard of O-Phospho-L-serine (HY-15129). This product is intended for research and analytical applications. O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8). O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
    O-Phospho-L-serine (Standard)
  • HY-110070

    2-Amino-4-phosphonobutyric acid sodium

    mGluR Others Neurological Disease
    DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes .
    DL-AP4 sodium
  • HY-115860

    iGluR Neurological Disease
    TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects .
    TAS-4

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