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MARK4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (2) AMPK (2) Apoptosis (2) CDK (2) Cyclin G-associated Kinase (GAK) (1) Ephrin Receptor (1) FGFR (1) IRAK (1) Itk (1) LIM Kinase (LIMK) (1) MAP4K (1) MARK (5) MELK (1) p38 MAPK (1) PROTACs (2) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (3) ULK (1) Wee1 (2)
By Research Areas:	Cancer (6) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-154986

MARK4 inhibitor 2	MARK AMPK	Cancer
MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an K_m of 6.3×10 ⁷ and an IC₅₀ of 0.82 μM. MARK4 inhibitor 2 inhibits the growth of human cells and can be used for cancer research .

HY-154988

MARK4 inhibitor 4	MARK	Neurological Disease Cancer
MARK4 inhibitor 4 is a *MARK4* inhibitor with an IC₅₀ of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research .

HY-114317

MARK4 inhibitor 1	MARK AMPK Apoptosis	Cancer
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC₅₀ of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis .

HY-154987

MARK4 inhibitor 3	MARK	Cancer
MAPK4 inhibitor 3 (compound 23b) is an inhibitor of *MAPK4* with an IC₅₀ value of 1.01 μM. MAPK4 inhibitor 3 inhibits cancer cells growth. MAPK4 inhibitor 3 can be used for research on cancer and tauopathies .

HY-139604

PCC0208017 1 Publications Verification	MARK Apoptosis	Cancer
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC₅₀s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC₅₀s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .

HY-148065

FMF-06-098-1	PROTACs Wee1 CDK AAK1 ULK MELK Itk IRAK Ephrin Receptor FGFR MAP4K p38 MAPK	Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 (Pink: target protein ligand (HY-169396); Blue: VHL ligand (HY-112078); Black: Linker (HY-124380)) .

HY-148062

RSS0680	PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1	Others
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, *CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl*. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].

HY-RS24656

Mark4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mark4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mark4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mark4 Rat Pre-designed siRNA Set A Mark4 Rat Pre-designed siRNA Set A

HY-RS08152

MARK4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MARK4 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARK4 Human Pre-designed siRNA Set A MARK4 Human Pre-designed siRNA Set A

HY-RS18182

Mark4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mark4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mark4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mark4 Mouse Pre-designed siRNA Set A Mark4 Mouse Pre-designed siRNA Set A

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701808

	MARK4 Protein, Human MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human is the recombinant human-derived MARK4 protein, expressed by E. coli , with tag free.

HY-P701809

	MARK4 Protein, Human (His) MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human (His) is the recombinant human-derived MARK4 protein, expressed by E. coli , with N-6*His labeled tag.

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Mark4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mark4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mark4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARK4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MARK4 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mark4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mark4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mark4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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