2. Search Result
Search Result
Results for "

L1210 leukemia

" in MedChemExpress (MCE) Product Catalog:

58

Inhibitors & Agonists

2

Peptides

27

Natural
Products

2

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129861
    5'-Ethynyl-2'-deoxycytidine

    		HSV Infection Cancer
    5'-Ethynyl-2'-deoxycytidine is an inhibitor for HSV, that inhibits the cytopathic effect of HSV-1 in primary rabbit kidney cell with a MIC of 0.2 μg/mL. 5'-Ethynyl-2'-deoxycytidine inhibits the proliferation of leukemia L1210 cell with an IC50 of 64.5 μg/mL .
    5'-Ethynyl-2'-deoxycytidine
  • HY-W194107
    Antitumor agent-152

    		DNA/RNA Synthesis Cancer
    Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM .
    Antitumor agent-152
  • HY-N10206
    11-epi-Chaetomugilin I

    		Endogenous Metabolite Cancer
    11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
    11-epi-Chaetomugilin I
  • HY-129564
    Acetomycin

    		Antibiotic Cancer
    Acetomycin is an antibiotic. Acetomycin inhibits the growth of CT-8 human colon adenocarcinoma cells (IC50: 1.5 μg/mL) and L1210 murine leukemia cells (IC50: 2.2 μg/mL). Acetomycin can be isolated from actinomycete WP-2661 .
    Acetomycin
  • HY-121412
    Lankacidin C

    		Antibiotic Bacterial Infection Cancer
    Lankacidin C is an inhibitor of protein synthesis in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity .
    Lankacidin C
  • HY-113578
    PD 116152

    		Antibiotic Bacterial Infection Cancer
    PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC50 values of 5.2 x 10 -7 M and 7.1 x 10 -7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia .
    PD 116152
  • HY-10082A
    (E)-3-AP

    (E)-PAN-811; (E)-NSC# 663249; (E)-OCX191

    		 DNA/RNA Synthesis Cancer
    (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis .
    (E)-3-AP
  • HY-122518
    8-Deazafolic acid

    		Bacterial Inflammation/Immunology
    8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice .
    8-Deazafolic acid
  • HY-N8519
    Urdamycin B

    		Bacterial Fungal Antibiotic Infection Cancer
    Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections .
    Urdamycin B
  • HY-129762
    Yoshi-864

    NSC-102627

    		 DNA/RNA Synthesis Cancer
    Yoshi-864 (NSC-102627) is an alkylsulfonate DNA crosslinker with anticancer activity. Yoshi-864 extends markedly the survival times of mice bearing L1210 leukemia or Ehrlich ascites carcinoma. Yoshi-864 also has a persistent reduction in ability to synthesize DNA in tumor cells from mice bearing the Ehrlich tumor .
    Yoshi-864
  • HY-129983
    5-Hydroxymethyl-2'-deoxyuridine

    		HSV Infection Cancer
    5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia .
    5-Hydroxymethyl-2'-deoxyuridine
  • HY-113700
    PD 116779

    		Antibiotic Cancer
    PD 116779 is an Antibiotic with anticancer activity. PD 116779 demonstrates moderate cytotoxicity against L1210 lymphocytic leukemia and HCT-8 human colon adenocarcinoma cell lines with IC50 values of 3.55x10 -7 and 4.08x10 -7 M, respectively .
    PD 116779
  • HY-N15034
    7-Hydroxyguanine

    		Antibiotic Bacterial Infection
    7-Hydroxyguanine is an antibiotic that can inhibit the growth of L1210 leukemia cells .
    7-Hydroxyguanine
  • HY-N14787
    Basidalin

    		Bacterial Infection Cancer
    Basidalin has the ability of anti-Gram-positive bacteria, negative bacteria and inhibition of mouse leukemia L-1210 cell.
    Basidalin
  • HY-126824
    5,10-Dideazaaminopterin

    		DNA/RNA Synthesis Cancer
    5,10-Dideazaaminopterin (compound 1) is a new compound with activity against L1210 leukemia with an IC50 value of 17nM .
    5,10-Dideazaaminopterin
  • HY-10939
    (-)-15-Deoxyspergualin

    		Bacterial Fluorescent Dye Cancer
    (-)-15-Deoxyspergualin is a potent antitumor agent. (-)-15-Deoxyspergualin shows strong inhibition against mouse leukemia L-1210 .
    (-)-15-Deoxyspergualin
  • HY-N14697
    Cytorhodin X

    		Antibiotic Cancer
    Cytorhodin X is a cytotoxic antibiotic. Cytorhodin X can inhibit the proliferation of L1210 murine leukemia cells, with an ED50 of 0.36 μM .
    Cytorhodin X
  • HY-10939A
    (-)-15-Deoxyspergualin trihydrochloride

    		Biochemical Assay Reagents Cancer
    (-)-15-Deoxyspergualin trihydrochloride is a potent antitumor agent. (-)-15-Deoxyspergualin trihydrochloride shows strong inhibition against mouse leukemia L-1210 .
    (-)-15-Deoxyspergualin trihydrochloride
  • HY-105969
    Dichloromethotrexate

    NSC-29630; 3',5'-Dichloromethotrexate

    		 Drug Derivative Cancer
    Dichloromethotrexate (NSC-29630), an orally active antitumor agent, shows antitumor effect against L1210 leukemia and C3H lymphosarcoma in mice .
    Dichloromethotrexate
  • HY-N13894
    Auramycin A

    		Antibiotic Bacterial Infection Cancer
    Auramycin A, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin A also exhibits antitumor activity against P388 and L1210 leukemia in mice .
    Auramycin A
  • HY-N14993
    3' -Deoxytalopiericidin

    		Others Cancer
    3'-Deoxytalopiericidin is found in the strain of Streptomyces sp.DO-100. 3'-Deoxytalopiericidin inhibited the activity of 26 cell in rectal cancer than L1210 cell in leukemia .
    3' -Deoxytalopiericidin
  • HY-N14617
    Rhodirubin A

    		Bacterial Infection Cancer
    Rhodirubin A has a strong anti-Gram-positive bacteria effect, and also has an effect on Mycobacterium. Rhodirubin A can also prolong the survival time of mice inoculated with leukemia L-1210 .
    Rhodirubin A
  • HY-N13895
    Auramycin B

    		Antibiotic Bacterial Infection Cancer
    Auramycin B, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin B also exhibits antitumor activity against P388 and L1210 leukemia in mice .
    Auramycin B
  • HY-N14619
    Rhodirubin B

    		Bacterial Infection Cancer
    Rhodirubin B has a strong anti-Gram-positive bacteria effect, and also has an effect on Mycobacterium. Rhodirubin B can also prolong the survival time of mice inoculated with leukemia L-1210 .
    Rhodirubin B
  • HY-N14764
    2-Hydroxyaclacinomycin A

    		DNA/RNA Synthesis Antibiotic Bacterial Infection Cancer
    2-Hydroxyaclacinomycin A is an anthracycline antibiotic. 2-Hydroxyaclacinomycin A has the activity of inhibiting leukemia L-1210 cells, and the IC50 for RNA and DNA synthesis is 0.10 μg/mL and 0.95 μg/mL, respectively .
    2-Hydroxyaclacinomycin A
  • HY-N2108
    7-Ethylcamptothecin

    		ADC Cytotoxin Cancer
    7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminata, is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models .
    7-Ethylcamptothecin
  • HY-126170
    Valanimycin

    		Antibiotic Bacterial Infection Cancer
    Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC50 of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice .
    Valanimycin
  • HY-N14806
    Napyradiomycin C1

    		Antibiotic Bacterial Infection
    Napyradiomycin C1 is an antibiotic with anti-Gram-positive bacteria and mycobacterial activity. Napyradiomycin C1 almost none to Gram-negative bacteria and fungi. IC50 (μg/mL) of leukemia L-1210 cells is 9.2 .
    Napyradiomycin C1
  • HY-N14802
    Napyradiomycin B1

    		Antibiotic Bacterial Infection
    Napyradiomycin B1 is an antibiotic with anti-Gram-positive bacteria and mycobacterial activity. Napyradiomycin B1 almost none to Gram-negative bacteria and fungi. IC50 (μg/mL) of leukemia L-1210 cells is 2.2 .
    Napyradiomycin B1
  • HY-N14652
    Glycocinnasperimicin D

    		Antibiotic Bacterial Infection Cancer
    Glycocinnasperimicin D is a glycoside cinnamyl imide histamine antibiotic. Glycocinnasperimicin D has the activity of anti-Gram positive bacteria and negative bacteria. Glycocinnasperimicin D inhibits leukemia L1210 cell with an IC50 of 2.0 μg/mL .
    Glycocinnasperimicin D
  • HY-119261
    Ruboxyl

    		Antibiotic Cancer
    Ruboxyl is an anthracycline antibiotic with antitumor activity. Ruboxyl inhibits colorectal cancer (CRC) liver metastasis in mice by 84%, suppresses B16 melanoma growth, and increases the survival rate of mice with L1210 or L5178Y leukemia .
    Ruboxyl
  • HY-N14776
    11-Demethyltomaymycin

    		Antibiotic Bacterial Infection Cancer
    11-Demethyltomaymycin is an antibiotic. 11-Demethyltomaymycin has antiviral activity against Escherichia coli T1 and T3 phages and antibacterial activity against Gram-positive bacteria. In addition, 11-Demethyltomaymycin is cytotoxic to leukemia L1210 cells .
    11-Demethyltomaymycin
  • HY-N14625
    Harziphilone

    		Bacterial Infection Cancer
    Harziphilone has weak anti-Gram-positive bacterial activity and anti-tumor effect, it can inhibit lymphoblastic leukemia L1210 and leukemia P388 with IC50 of 0.26 μg/mL. Harziphilone inhibits the binding of viral particle regulatory (REV) proteins to [ 33P] labeled viral particle regulatory effector element (RRE) RNA, IC50 is 2.0 μM .
    Harziphilone
  • HY-130430
    Neplanocin A

    (-)-Neplanocin A

    		 Antibiotic Orthopoxvirus Infection Cancer
    Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis .
    Neplanocin A
  • HY-N2108R
    7-Ethylcamptothecin (Standard)

    		ADC Cytotoxin Cancer
    7-Ethylcamptothecin (Standard) is the analytical standard of 7-Ethylcamptothecin. This product is intended for research and analytical applications. 7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminata, is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models .
    7-Ethylcamptothecin (Standard)
  • HY-101775
    9-Hydroxyellipticin

    		Topoisomerase Cardiovascular Disease Cancer
    9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice .
    9-Hydroxyellipticin
  • HY-117285
    Medermycin

    Lactoquinomycin A; LQM-A

    		 Antibiotic Bacterial Infection Cancer
    Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively .
    Medermycin
  • HY-N14774
    Lactoquinomycin B

    		Antibiotic Bacterial Infection
    Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively .
    Lactoquinomycin B
  • HY-130059
    Guanine-7-oxide

    Guanine 7-N-oxide

    		 Antibiotic Fungal HSV Infection Cancer
    Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with anti-tumor, anti-Candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. Guanine-7-oxide has good activity against mouse L1210 leukemia cells .
    Guanine-7-oxide
  • HY-124093
    8-Deazahomofolic acid

    		Thymidylate Synthase Bacterial Infection Cancer
    8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors .
    8-Deazahomofolic acid
  • HY-N10653
    Altemicidin

    (-)-Altemicidin

    		 Others Cancer
    Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
    Altemicidin
  • HY-W344074
    Cytarabine 5’-monophosphate

    		DNA/RNA Synthesis Drug Metabolite Cancer
    Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine (HY-13605), catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research .
    Cytarabine 5’-monophosphate
  • HY-159803
    IST-622

    6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin

    		 Endogenous Metabolite Cancer
    IST-622 (6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin) is an anti-tumor agent with significant growth inhibitory activity. IST-622 exhibits significant anti-tumor effects against a variety of mouse tumors such as P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, Colon 26 and Colon 38 adenocarcinomas, and M5076 reticulum cell sarcoma. IST-622 was orally administered and the results showed efficacy in different tumor types. In addition, IST-622 provided significant inhibitory effects against two human tumor xenograft models: large cell lung carcinoma (Lu-116) and gastric adenocarcinoma (St-4). IST-622 also exhibited significant growth inhibitory activity against P388 leukemia in vitro, with a half inhibitory concentration (IC50) more than 20 times lower than CT .
    IST-622
  • HY-123597
    NSC 109555

    DDUG; NCI C04808

    		 Autophagy Checkpoint Kinase (Chk) Cancer
    NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2; IC50=200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC50 values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC50=240 nM). It inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro.2 NSC 109555 (1,250 nM) potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of reactive oxygen species (ROS) in MIA PaCa-2 cells.
    NSC 109555
  • HY-116028
    15-deoxy-Δ12,14-Prostaglandin D2

    15-Deoxy-Δ12,14-PGD2

    		 Endogenous Metabolite Prostaglandin Receptor PPAR Src Cardiovascular Disease
    15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC50=8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC50=320 ng/mL).
    15-deoxy-Δ12,14-Prostaglandin D2
  • HY-115836
    DDPO

    		Dihydrofolate reductase (DHFR) Cancer
    DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 µM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 µM .
    DDPO
  • HY-120293
    CB30900

    		Thymidylate Synthase Cancer
    CB30900 is an inhibitor for thymidylate synthase with an IC50 of 0.2 μM. CB30900 exhibits cytotoxicity in W1L2 with an IC50 of 0.13 μM .
    CB30900
  • HY-105270
    Tallimustine

    FCE 24517

    		 Drug Derivative Cancer
    Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent .
    Tallimustine
  • HY-103159
    1-Deazaadenosine

    		Adenosine Deaminase Cancer
    1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders .
    1-Deazaadenosine
  • HY-W077242
    1,4-Anthraquinone

    		DNA/RNA Synthesis Cancer
    1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia .
    1,4-Anthraquinone

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: