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KIF18A inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Drug Isomer (1) Kinesin (20) Microtubule/Tubulin (16)
By Research Areas:	Cancer (20)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162110

AM-9022	Kinesin Microtubule/Tubulin	Cancer
AM-9022 is an orally active, potent, selective *KIF18A* inhibitor that can be used for research on cancer .

HY-153065

KIF18A-IN-6	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-6 (Compound 134) is an orally active *KIF18A* inhibitor with an IC₅₀ of 0.016 μM against KIF18A microtubule-dependent ATPase activity .

HY-145034

KIF18A-IN-1 1 Publications Verification	Kinesin	Cancer
KIF18A-IN-1 is an inhibitor of the mitotic kinesin *KIF18A* with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells .

HY-145803

KIF18A-IN-3	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-3 is a potent *KIF18A* inhibitor (IC₅₀=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer .

HY-145802

KIF18A-IN-2	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-2 is a potent *KIF18A* inhibitor (IC₅₀=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer .

HY-158757

KIF18A-IN-12	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-12 (compound 9) is a *KIF18A* inhibitor, with an IC₅₀ value of 45.54 nM. KIF18A-IN-12 can be used in cancer research .

HY-162937

KIF18A-IN-13	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-13 (Compound 16) is an effective and orally active inhibitor of *KIF18A* with anticancer activity in vivo. KIF18A-IN-13 can be utilized for research in ovarian cancer .

HY-164980

KIF18A-IN-16	Kinesin	Cancer
KIF18A-IN-16 (Compound 15) is a fused ring *KIF18A* inhibitor. KIF18A-IN-16 can be used in oncology (e.g., colon, breast, lung cancer) studies .

HY-158683

KIF18A-IN-11	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-11 (Compound 13) is a potent *KIF18A* inhibitor, with IC₅₀ values of less than 100 nM in OVCAR3 and MDA-MB-157 cells. KIF18A-IN-11 can be used for the research of cancer .

HY-145827

KIF18A-IN-4	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive *KIF18A* inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity .

HY-162532

KIF18A-IN-10	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-10 (Compound 24) is a potent *KIF18A* inhibitor, with an IC₅₀ value of 23.8 nM. KIF18A-IN-10 has anticancer activity, with IC₅₀ values of less than 100 nM in OVCAR3 and MDA-MB-157 cells .

HY-162531

KIF18A-IN-9	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-9 (Compound 1) is a potent *KIF18A* inhibitor, with an IC₅₀ value of 3.8 nM. KIF18A-IN-9 has anticancer activity, with IC₅₀ values of less than 100 nM in OVCAR3 and MDA-MB-157 cells .

HY-164978

KIF18A-IN-14	Kinesin	Cancer
KIF18A-IN-14 (Compound Example 81) is a *KIF18A* inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC₅₀s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies .

HY-144894

AM-5308	Kinesin Microtubule/Tubulin	Cancer
AM-5308 is the inhibitor for *KIF18A* (IC₅₀=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity .

HY-153066

VLS-1272 KIF18A-IN-7	Kinesin Microtubule/Tubulin Apoptosis	Cancer
VLS-1272 (Compound 22) is an orally active *KIF18A* inhibitor that binds to the KIF18A-microtubule complex in an ATP-noncompetitive manner (IC₅₀ = 41 nM), blocking its ATPase activity and inhibiting microtubule translocation. This leads to abnormal accumulation of KIF18A at spindle poles, disrupting chromosome alignment and inducing mitotic arrest and apoptosis in CIN ^High tumor cells (e.g., ovarian cancer OVCAR-3, breast cancer JIMT-1). VLS-1272 is a promising candidate for anti-tumor research .

HY-101770

BTB-1	Kinesin Microtubule/Tubulin	Cancer
BTB-1 is a potent, selective and reversible mitotic motor protein *Kif18A* inhibitor with an IC₅₀ of 1.69 μM.

HY-162667

EX05	Kinesin Microtubule/Tubulin	Cancer
EX05 is a potent *KIF18A* inhibitor with an IC₅₀ value of 8.2 nM. EX05 has the potential for the research of cancer .

HY-164979

KIF18A-IN-15	Kinesin	Cancer
KIF18A-IN-15 (Compound Example 36) is a *KIF18A* inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC₅₀s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC₅₀s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies .

HY-132840

Sovilnesib 1 Publications Verification AMG 650	Kinesin Microtubule/Tubulin	Cancer
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC₅₀ value of 0.071 μM. Sovilnesib can be used for the research of cancer .

HY-162110A

(S)-AM-9022	Kinesin Microtubule/Tubulin Drug Isomer	Cancer
(S)-AM-9022 is the S-enantiomer of AM-9022 (HY-162110). AM-9022 is an orally active, potent, selective *KIF18A* inhibitor that can be used for research on cancer .

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KIF18A inhibitor

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