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JET-209

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-154984
    JET-209

    		Histone Acetyltransferase PROTACs Cancer
    JET-209 is a potent CBP/p300 PROTAC degrader, with DC50 values of 0.05 nM and 0.2 nM for CBP and p300. JET-209 demonstrates remarkable anti-tumor activity against various acute leukemia cell lines and effectively inhibits tumor growth in xenograft tumor models. JET-209 can be used for the study of acute leukemia (Pink: CBP/p300 ligand (HY-175620); Blue: CRBN ligand (HY-132248); Black: Linker; CBP/p300 ligand + Linker (HY-175621)) .
    JET-209

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