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Results for "

IRF3 and p65

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

2

Fluorescent Dye

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0162
    Malachite green hemioxalate
    1 Publications Verification

    MCCK1

    		 Fungal IKK NF-κB Apoptosis Infection Cancer
    Malachite green hemioxalate (MCCK1) is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antibacterial activity, which is attributed to inhibition of intracellular enzymes, insertion into DNA and/or interaction with cell membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo .
    Malachite green hemioxalate
  • HY-149724
    Anti-inflammatory agent 65

    		STING NO Synthase Inflammation/Immunology
    Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response .
    Anti-inflammatory agent 65
  • HY-D0162R
    Malachite green hemioxalate (Standard)

    MCCK1 (Standard)

    		 Reference Standards Fungal IKK NF-κB Apoptosis Infection Cancer
    Malachite green hemioxalate (Standard) is the analytical standard of Malachite green hemioxalate (HY-D0162). This product is intended for research and analytical applications. Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antimicrobial activity, which is attributed to inhibition of intracellular enzymes, intercalation into DNA, and/or interaction with cellular membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo.
    Malachite green hemioxalate (Standard)
  • HY-176192
    SMU-14a

    		Toll-like Receptor (TLR) TNF Receptor NF-κB p38 MAPK ERK IKK Inflammation/Immunology
    SMU-14a is a TLR3 inhibitor (IC50: 0.18 µM). SMU-14a inhibits IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-α in human peripheral blood monocytes. SMU-14a exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 through NF-κB, MAPK, and IRF3 signaling pathways, and decreasing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. SMU-14a can be used in the study of acute hepatitis .
    SMU-14a

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