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Results for "

IGHE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Fc Receptor (FcR) (1) Histamine Receptor (1) Interleukin Related (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Inflammation/Immunology (5)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Quilizumab Anti-Human IGHE Recombinant Antibody	Apoptosis	Inflammation/Immunology
Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed *IGHE/IgE, leading to IGHE*/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research .

Ligelizumab 1 Publications Verification QGE 031; Anti-IGHE Recombinant Antibody	Fc Receptor (FcR)	Inflammation/Immunology
Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma) .

IGHE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGHE Human Pre-designed siRNA Set A contains three designed siRNAs for IGHE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGHE Human Pre-designed siRNA Set A IGHE Human Pre-designed siRNA Set A

Ighe Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ighe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ighe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ighe Mouse Pre-designed siRNA Set A Ighe Mouse Pre-designed siRNA Set A

XmAb-7195 AIMab-7195	Histamine Receptor	Inflammation/Immunology
XmAb-7195 (AIMab-7195) is a human monoclonal antibody (mAb) targeting *IGHE*. XmAb-7195 can be used in Food hypersensitivity, Allergic asthma, Allergic rhinitis, Atopic dermatitis and Conjunctivitis research .

FB-825	Interleukin Related	Inflammation/Immunology
FB-825 is a human monoclonal antibody (mAb) targeting *IGHE. FB-825 targets the CεmX domain of membrane IgE (mIgE*), resulting in the downregulation of mIgE-positive B cells and the production of IgE. FB-825 can be used in Allergic asthma, Atopic dermatitis, Job syndrome and Allergic rhinitis research .

Cat. No.	Product Name	Target	Research Area

Quilizumab Anti-Human IGHE Recombinant Antibody	Apoptosis	Inflammation/Immunology
Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed *IGHE/IgE, leading to IGHE*/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research .

Ligelizumab 1 Publications Verification QGE 031; Anti-IGHE Recombinant Antibody	Fc Receptor (FcR)	Inflammation/Immunology
Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma) .

XmAb-7195 AIMab-7195	Histamine Receptor	Inflammation/Immunology
XmAb-7195 (AIMab-7195) is a human monoclonal antibody (mAb) targeting *IGHE*. XmAb-7195 can be used in Food hypersensitivity, Allergic asthma, Allergic rhinitis, Atopic dermatitis and Conjunctivitis research .

Ozureprubart	Inhibitory Antibodies	Inflammation/Immunology
HY-P990936 is an *IGHE*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

FB-825	Interleukin Related	Inflammation/Immunology
FB-825 is a human monoclonal antibody (mAb) targeting *IGHE. FB-825 targets the CεmX domain of membrane IgE (mIgE*), resulting in the downregulation of mIgE-positive B cells and the production of IgE. FB-825 can be used in Allergic asthma, Atopic dermatitis, Job syndrome and Allergic rhinitis research .

Cat. No.	Compare	Product Name	Species	Source

	IgE Protein, Human (HEK293, His) Immunoglobulin heavy constant epsilon; IGHE; IgE	Human	HEK293
	IgE protein is an important immunoglobulin component that participates in the recognition and effector phases of humoral immunity. As a membrane-bound receptor on B lymphocytes, IgE triggers clonal expansion upon antigen binding, leading to plasma cell differentiation. IgE Protein, Human (HEK293, His) is the recombinant human-derived IgE protein, expressed by HEK293 , with C-His labeled tag.

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IGHE Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGHE Human Pre-designed siRNA Set A contains three designed siRNAs for IGHE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ighe Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ighe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ighe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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