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Results for "

Human African Trypanosomiasis

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155655
    JC-229

    		Parasite Infection
    JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .
    JC-229
  • HY-120060
    GNF6702

    		Parasite Infection
    GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .
    GNF6702
  • HY-Q40175
    Antitrypanosomal agent 9

    		Parasite Infection
    Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .
    Antitrypanosomal agent 9
  • HY-19910
    Acoziborole
    1 Publications Verification

    SCYX-7158; AN5568

    		 Parasite Infection
    Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 μg/mL .
    Acoziborole
  • HY-N12636
    Kagimminol A

    		Parasite Infection
    Kagimminols A is a cembrene-type diterpenoids and can be isolated from an Okeania sp. marine cyanobacterium. Kagimminols A shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .
    Kagimminol A
  • HY-151195
    20S Proteasome-IN-4

    		Proteasome Parasite Infection
    20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .
    20S Proteasome-IN-4
  • HY-122382
    Levofuraltadone

    NF-602

    		 Parasite Bacterial Infection
    Levofuraltadone (NF-602) is an antibacterial and antiparasitic agent. Levofuraltadone has anti-trypanosomiasis activity and can be used in the study of human african trypanosomiasis as well as bacterial infections .
    Levofuraltadone
  • HY-155024
    HAT-IN-8

    		Parasite Infection
    HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC50: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .
    HAT-IN-8
  • HY-N12637
    Kagimminol B

    		Parasite Infection
    Kagimminol B, a cembrene-type diterpenoid, can be isolated from an Okeania sp. marine cyanobacterium. Kagimminol B shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .
    Kagimminol B
  • HY-155025
    Antitrypanosomal agent 14

    		Parasite GSK-3 Infection
    Antitrypanosomal agent 14 (Compound 1) is a T. brucei inhibitor (EC50: 0.47 μM). Antitrypanosomal agent 14 inhibits TbGSK3 with an IC50 of 12 μM. Antitrypanosomal agent 14 can be used for the research of Human African trypanosomiasis .
    Antitrypanosomal agent 14
  • HY-125084
    NEU617

    		Parasite Infection
    NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC50: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898) .
    NEU617
  • HY-103056
    DDD85646

    IMP-366

    		 DNA/RNA Synthesis Parasite Infection
    DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646
  • HY-W726137
    Potassium 1,2-naphthoquinone-4-sulphonate

    		Drug Intermediate Infection
    Potassium 1,2-naphthoquinone-4-sulphonate (Compound 16) is a 6-phosphogluconate dehydrogenase (6PGDH) inhibitor with an IC50 of 53 μM. Potassium 1,2-naphthoquinone-4-sulphonate can be used in the study of human African trypanosomiasis .
    Potassium 1,2-naphthoquinone-4-sulphonate
  • HY-136637
    NPD-001

    		Phosphodiesterase (PDE) Parasite Infection
    NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM .
    NPD-001
  • HY-155732
    NPD-2975

    		Parasite Infection
    NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .
    NPD-2975
  • HY-150506
    SPR7

    		Parasite Infection
    SPR7 (compound 7) is a potent and selective rhodesain inhibitor, with a Ki of 0.51 nM. SPR7 shows antiparasitic activity against T. b. brucei, with an EC50 of 1.65 μM .
    SPR7
  • HY-119480R
    Megazol (Standard)

    		Bacterial Infection
    Megazol (Standard) is the analytical standard of Megazol. This product is intended for research and analytical applications. Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
    Megazol (Standard)
  • HY-119480
    Megazol

    		Bacterial Infection
    Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
    Megazol

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