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HIV-1 RNase H

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150759
    HIV-1 inhibitor-45

    		HIV Infection
    HIV-1 inhibitor-45 is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity. HIV-1 inhibitor-45 shows poor cell permeability (with an apparent permeability coefficient (Papp) lower than 0.48 × 10 −6 cm/s) .
    HIV-1 inhibitor-45
  • HY-W028350
    NSC727447

    		HIV DNA/RNA Synthesis Infection
    NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively .
    NSC727447
  • HY-W103287
    2-Hydroxyisoquinoline-1,3(2H,4H)-dione

    		HIV Integrase Infection
    Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC50 value of 6.32, 5.9 µM, respectively .
    2-Hydroxyisoquinoline-1,3(2H,4H)-dione
  • HY-132572
    HIV-1 integrase inhibitor 9

    		HIV Infection
    HIV-1 integrase inhibitor 9 (compound 8a) is a potent HIV-1 RNase H inhibitor with an IC50 of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity .
    HIV-1 integrase inhibitor 9
  • HY-116454
    GSK5750

    		Reverse Transcriptase HIV Infection
    GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism .
    GSK5750

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