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Results for "

HFIP

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

3

Peptides

1

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1363B
    β-Amyloid (1-42), human, HFIP-treated
    10+ Cited Publications

    		 Amyloid-β Neurological Disease
    β-Amyloid (1-42), human, HFIP-treated is a β-Amyloid (1-42), human (HY-P1363A) treated with HFIP. β-Amyloid (1-42), human (Amyloid β-Peptide (1-42) (human)) is a 42-amino acid peptide that causes neurotoxicity, which is related to the pathogenesis of Alzheimer's disease. β-Amyloid (1-42), human specifically interacts with the promoters of genes like LRP1 and KAI1. β-Amyloid (1-42), human can form oligomers and fibrils in vitro, and the oligomeric form is more neurotoxic than the fibrillar form .
    β-Amyloid (1-42), human, HFIP-treated
  • HY-18977
    KML29
    2 Publications Verification

    		 MAGL Metabolic Disease Inflammation/Immunology
    KML29 is an extremely selective, orally active and irreversible MAGL inhibitor, with IC50 values of 15 nM, 43 nM and 5.9 nM for mouse, rat and human MAGL, respectively. KML29 exhibits minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH .
    KML29
  • HY-P1363A
    β-Amyloid (1-42), human
    10+ Cited Publications

    Amyloid β-peptide (1-42) (human)

    		 Amyloid-β Neurological Disease
    β-Amyloid (1-42) (Amyloid β-peptide (1-42), human) (not treated with HFIP), human, a 42-amino acid peptide, is a brain-penetrant amyloid protein fragment associated with Alzheimer's disease. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can be diluted with cold PBS or basic medium at 4 ℃ for incubation to form soluble oligomers (AβOs), which have synaptic toxicity and neurotoxicity; on the other hand, it can be diluted with HCl and incubated at 37 ℃ to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process.β-Amyloid (1-42), human also regulates cholesterol transport. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death. β-Amyloid (1-42) can be used in research on Alzheimer's disease and Down’s syndrome .
    β-Amyloid (1-42), human
  • HY-RS04950
    FIP1L1 Human Pre-designed siRNA Set A

    Rhe; FIP1; HFIP1

    		 Small Interfering RNA (siRNA) Others

    FIP1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for FIP1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FIP1L1 Human Pre-designed siRNA Set A
    FIP1L1 Human Pre-designed siRNA Set A
  • HY-P0128A
    β-Amyloid (25-35), HFIP-treated

    Amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-Amyloid peptide (25-35), HFIP-treated

    		 Amyloid-β Neurological Disease
    β-Amyloid (25-35) (Amyloid beta-peptide (25-35)), HFIP-treated is a β-Amyloid (25-35) (HY-P0128) treated with HFIP. β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .
    β-Amyloid (25-35), HFIP-treated

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