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Results for "

EROD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aryl Hydrocarbon Receptor (4) Cytochrome P450 (8) Estrogen Receptor/ERR (1) Glutathione S-transferase (1) Isotope-Labeled Compounds (1)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (6)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W100026

Galaxolide	Estrogen Receptor/ERR Glutathione S-transferase	Metabolic Disease Endocrinology
Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), trigger oxidative stress and genotoxicity, and induce EROD and GST (Glutathione S-transferase) enzyme activity .

HY-B2187

Diacetazotol Diacetotoluide	Others	Metabolic Disease
Diacetazotol inhibits dioxin-induced ethoxyresorufin-O-deethylase (EROD) activity with IC₅₀ of 75±4 nM. Diacetazotol extracts from patent US20070032458, compound 3.

HY-112734

4'-Methylchrysoeriol	Cytochrome P450	Cancer
4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC₅₀ of 19 nM for human P450 1B1-dependent EROD.

HY-B0973

Dibenzothiophene DBT; Diphenylene sulfide	Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated *EROD* activity with a K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-B0973S

Dibenzothiophene-d8	Isotope-Labeled Compounds Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated *EROD* activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-W762018

2,3,4,6,7,8-Hexachlorodibenzofuran 2,3,4,6,7,8-HxCDF	Cytochrome P450	Infection Cancer
2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC₅₀s = 0.687 and 0.575 nM, respectively) .

HY-W762015

1,2,3,6,7,8-Hexachlorodibenzofuran 1,2,3,6,7,8-HxCDF	Cytochrome P450	Cancer
1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC₅₀s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC₅₀s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively) .

HY-W762012

Octachlorodibenzo-p-dioxin OCDD	Cytochrome P450	Others
Octachlorodibenzo-p-dioxin (OCDD) is an environmental contaminant but is not acutely toxic. In rats, Octachlorodibenzo-p-dioxin (50 μg/kg i.v. or 50-5000 μg/kg p.o.) has a systemic elimination half-life of 3-5 months and accumulates and concentrates in the liver and adipose tissue after low-dose, repeated exposure. Repeated administration of octachlorodibenzo-p-dioxin causes increases in 7-ethoxyresorufin-O-deethylase (7-EROD) activity and total cytochrome P-450 levels .

HY-B0973R

Dibenzothiophene (Standard) DBT (Standard); Diphenylene sulfide (Standard)	Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene (Standard) is the analytical standard of Dibenzothiophene (HY-B0973). This product is intended for research and analytical applications. Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated *EROD* activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-W517092

1,2,3,4,7,8,9-Heptachlorodibenzofuran 1,2,3,4,7,8,9-HpCDF	Aryl Hydrocarbon Receptor Cytochrome P450	Metabolic Disease Inflammation/Immunology
1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR). 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology .

Cat. No.	Product Name	Chemical Structure

HY-B0973S

Dibenzothiophene-d8
Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated *EROD* activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

Dibenzothiophene-d8

Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

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