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Results for "

Drp1-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) Antibiotic (1) Apoptosis (1) ATP Synthase (1) Dynamin (8) Isotope-Labeled Compounds (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (8) Infection (2) Inflammation/Immunology (3) Neurological Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Dan family AIM2 NEKs CD44

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125222

*Drp1-IN-1*	Dynamin	Others
Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC₅₀ of 0.91 μM .

HY-P2280

TAT-P110 P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 .

HY-155656

Anti-inflammatory agent 49	Dynamin	Inflammation/Immunology
nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of *Drp1-Fis1* interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC₅₀ of SC9 inhibiting GTPase in vitro is 270 nM .

HY-P10368

P110 heptapeptide	Dynamin Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
P110 heptapeptide is a peptide inhibitor of the *Drp1-Fis1* interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of *Drp1*, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases .

HY-P6374

IIQLPEIVVV TFA	Dynamin	Neurological Disease
IIQLPEIVVV TFA is a specific inhibitor of *Drp1-Mff* interaction. IIQLPEIVVV TFA can distinguish physiological from pathological fission and block physiological fission, thus leading to mitochondrial dysfunction. IIQLPEIVVV TFA can be used in the study of Huntington's disease .

HY-13338

Mabuterol	Adrenergic Receptor	Cardiovascular Disease
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-152086

DRP1i27	Dynamin	Cardiovascular Disease
DRP1i27 is a potent inhibitor of human *Drp1* (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-P11005

P259	Dynamin ATP Synthase	Neurological Disease
P259 is a *Drp1-Mff* inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model .

HY-W755295

Mabuterol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-125918

Bleomycin A5 hydrochloride PINgyangmycIN hydrochloride	Apoptosis Antibiotic	Infection Cancer
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..

HY-152086A

DRP1i27 dihydrochloride	Dynamin	Cardiovascular Disease
DRP1i27 dihydrochloride is a potent inhibitor of human *Drp1* (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-152051S

Mabuterol-d9 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-W755295R

Mabuterol hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Mabuterol (hydrochloride) (Standard) is the analytical standard of Mabuterol (hydrochloride). This product is intended for research and analytical applications. Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-13338R

Mabuterol (Standard)	Adrenergic Receptor	Cardiovascular Disease
Mabuterol (Standard) is the analytical standard of Mabuterol. This product is intended for research and analytical applications. Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

Cat. No.	Product Name	Target	Research Area

HY-P2280

TAT-P110 P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 .

HY-P10368

P110 heptapeptide	Dynamin Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
P110 heptapeptide is a peptide inhibitor of the *Drp1-Fis1* interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of *Drp1*, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases .

HY-P6374

IIQLPEIVVV TFA	Dynamin	Neurological Disease
IIQLPEIVVV TFA is a specific inhibitor of *Drp1-Mff* interaction. IIQLPEIVVV TFA can distinguish physiological from pathological fission and block physiological fission, thus leading to mitochondrial dysfunction. IIQLPEIVVV TFA can be used in the study of Huntington's disease .

HY-P11005

P259	Dynamin ATP Synthase	Neurological Disease
P259 is a *Drp1-Mff* inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125918

Bleomycin A5 hydrochloride PINgyangmycIN hydrochloride	Structural Classification Microorganisms Antibiotics Source classification	Apoptosis Antibiotic
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..

Cat. No.	Product Name	Chemical Structure

HY-152051S

Mabuterol-d9 hydrochloride
Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

Mabuterol-d9 hydrochloride

Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

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