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Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

DNA alkylating agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (56) DNA-PK (1) DNA/RNA Synthesis (8) ADC Payload (10) Antibiotic (5) AP-1 (2) Apoptosis (26) ATM/ATR (1) Autophagy (5) Bacterial (4) Biochemical Assay Reagents (1) Caspase (1) Drug Derivative (1) Drug Metabolite (2) Drug-Linker Conjugates for ADC (5) FLAP (1) Isotope-Labeled Compounds (5) JNK (2) MDM-2/p53 (3) NAMPT (1) Necroptosis (2) p38 MAPK (2) Reactive Oxygen Species (ROS) (1) Reference Standards (5)
By Research Areas:	Cancer (71) Infection (4) Inflammation/Immunology (3) Neurological Disease (4)

By Targets:

DNA Alkylator/Crosslinker (56)

DNA-PK (1)

DNA/RNA Synthesis (8)

ADC Payload (10)

Antibiotic (5)

AP-1 (2)

Apoptosis (26)

ATM/ATR (1)

Autophagy (5)

Bacterial (4)

Biochemical Assay Reagents (1)

Caspase (1)

Drug Derivative (1)

Drug Metabolite (2)

Drug-Linker Conjugates for ADC (5)

FLAP (1)

Isotope-Labeled Compounds (5)

JNK (2)

MDM-2/p53 (3)

NAMPT (1)

Necroptosis (2)

p38 MAPK (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (5)

By Research Areas:

Cancer (71)

Infection (4)

Inflammation/Immunology (3)

Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: DNA-PK DNA Glycosylase DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W019815

N-Ethyl-N-nitrosourea ENU; N-Nitroso-N-ethylurea	DNA/RNA Synthesis	Neurological Disease Cancer
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders .

HY-17574

Thio-TEPA 2 Publications Verification	DNA Alkylator/Crosslinker Bacterial Antibiotic	Infection Cancer
Thio-TEPA is a **DNA alkylating** agent, with antitumor activity.

HY-13669

Lomustine 5 Publications Verification CCNU; NSC 79037	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Lomustine (CCNU; NSC 79037) is a **DNA alkylating** agent, with antitumor activity.

HY-16513

VAL-083 1 Publications Verification Dianhydrodulcitol; Dianhydrogalactitol	DNA Alkylator/Crosslinker	Cancer
VAL-083 is an *alkylating* agent that creates N7 methylation on DNA, with antitumor activity.

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent *alkylating* antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-N15366

N-Acetoxy-IQ	DNA Alkylator/Crosslinker	Cancer
N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to *DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA* adducts. N-Acetoxy-IQ is promising for research of cancers .

HY-B0733

Fotemustine S10036	DNA Alkylator/Crosslinker	Cancer
Fotemustine is a *DNA-alkylating* agent, with antitumor activity.

HY-16117A

Brostallicin PNU-166196	DNA Alkylator/Crosslinker	Cancer
Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity .

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-161051

Anticancer agent 177	NAMPT DNA Alkylator/Crosslinker	Cancer
Anticancer agent 177 (Compound 11b) is a NAMPT inhibitor and DNA alkylating agent. Anticancer agent 177 has antitumor activity in vitro and in vivo .

HY-114577

Palifosfamide tromethamine Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine	DNA Alkylator/Crosslinker	Cancer
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

HY-111397

Bizelesin 1 Publications Verification NSC 615291; U-77779	DNA Alkylator/Crosslinker	Cancer
Bizelesin (NSC 615291; U-77779) is an AT-specific **DNA alkylating** agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .

HY-17419A

(R)-Ifosfamide	Others	Cancer
(R)-Ifosfamide is a chemotherapeutic agent primarily used in the treatment of aggressive tumors such as rhabdomyosarcoma, exhibiting alkylating activity that interferes with DNA replication.

HY-119696

MTIC	Drug Metabolite	Neurological Disease Cancer
MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity .

HY-128873

Duocarmycin GA	ADC Payload DNA Alkylator/Crosslinker	Cancer
Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.

HY-107770

Duocarmycin MB	ADC Payload DNA Alkylator/Crosslinker	Cancer
Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.

HY-18987

Duocarmycin MA	ADC Payload DNA Alkylator/Crosslinker	Cancer
Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.

HY-14429

(-)-Irofulven MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863	DNA Alkylator/Crosslinker Apoptosis	Cancer
(-)-Irofulven (MGI 114), an Illudin S analog, is a **DNA alkylating** agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-B0077

Bendamustine hydrochloride 5 Publications Verification SDX-105	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-13669R

Lomustine (Standard) CCNU (Standard); NSC 79037 (Standard)	Reference Standards DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Lomustine (Standard) is the analytical standard of Lomustine. This product is intended for research and analytical applications. Lomustine (CCNU; NSC 79037) is a **DNA alkylating** agent, with antitumor activity.

HY-17574R

Thio-TEPA (Standard)	Reference Standards DNA Alkylator/Crosslinker Bacterial Antibiotic	Infection Cancer
Thio-TEPA (Standard) is the analytical standard of Thio-TEPA. This product is intended for research and analytical applications. Thio-TEPA is a DNA alkylating agent, with antitumor activity.

HY-W701673

Thio-TEPA-d12	Isotope-Labeled Compounds DNA Alkylator/Crosslinker Bacterial Antibiotic	Cancer
Thio-TEPA-d₁₂ is the deuterium labeled Thio-TEPA (HY-17574). Thio-TEPA is a DNA alkylating agent, with antitumor activity.

HY-128957

Vc-seco-DUBA 1 Publications Verification SYD985	Drug-Linker Conjugates for ADC	Cancer
Vc-seco-DUBA (SYD985) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco .

HY-136289

MB-VC-MGBA	Drug-Linker Conjugates for ADC	Cancer
MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC .

HY-B0245R

Busulfan (Standard)	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-W111005

1-Chloromethylpyrene	DNA Alkylator/Crosslinker	Cancer
1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells .

HY-13567

Bendamustine 5 Publications Verification SDX-105 free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-139453A

LP-284	DNA Alkylator/Crosslinker	Cancer
LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL) .

HY-128880

(+)-CBI-CDPI1	ADC Payload DNA Alkylator/Crosslinker	Cancer
(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody agent conjugates (ADCs) toxin.

HY-128881

(+)-CBI-CDPI2	ADC Payload DNA Alkylator/Crosslinker	Cancer
(+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody agent conjugates (ADCs) toxin.

HY-N9279

Dehydromonocrotaline Monocrotaline pyrrole; MCTP; 3,8-Didehydromonocrotaline	DNA Alkylator/Crosslinker	Others
Dehydromonocrotaline (Monocrotaline pyrrole) is the metabolite of Monocrotaline (HY-N0750). Dehydromonocrotaline is an alkylating agent, that reacts with DNA, exhibits cytotoxicity, and induces liver and lung damage .

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-19577

Ambamustine PTT119	DNA Alkylator/Crosslinker	Infection Cancer
Ambamustine (PTT119) is a new bifunctional **alkylating agent** and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities .

HY-101002

Sarcosinamide chloroethylnitrosourea SarCNU; Sarmustine	Apoptosis DNA Alkylator/Crosslinker	Cancer
Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent. Sarcosinamide chloroethylnitrosourea can induce apoptosis by promoting DNA alkylation. Sarcosinamide chloroethylnitrosourea can be used in cancer-related research .

HY-W588285

3-Methylguanine 3-MG	DNA/RNA Synthesis	Others
3-Methylguanine is a DNA damage product caused by alkylation. 3-Methylguanine is cytotoxic and causes cell death by inhibiting DNA replication. 3-Methylguanine can be used to study the mechanism of DNA damage caused by alkylating agents and its repair pathways .

HY-128904

MC-Val-Cit-PAB-duocarmycin chloride 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.

HY-W018326

Temozolomide acid	DNA/RNA Synthesis	Cancer
Temozolomide acid is a carboxylic acid derivative of Temozolomide (HY-17364) with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer .

HY-148091

Duocarmycin analog-2	DNA Alkylator/Crosslinker	Cancer
Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity .

HY-B0077S1

Bendamustine-d8 hydrochloride SDX-105-d₈	Isotope-Labeled Compounds DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-12457

Rachelmycin CC-1065; NSC 298223	Antibiotic DNA/RNA Synthesis	Infection Cancer
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .

HY-101150

DGN462	DNA Alkylator/Crosslinker ADC Payload	Cancer
DGN462, a potent *DNA-alkylating* agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-101150A

sulfo-DGN462 sodium	DNA Alkylator/Crosslinker ADC Payload	Cancer
sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML) .

HY-16398

Pipobroman	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Pipobroman is a bromide derivative of piperazine and acts as an **alkylating agent*. Pipobroman plays its role by inhibiting DNA* and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .

HY-119696R

MTIC (Standard)	Reference Standards Drug Metabolite	Neurological Disease Cancer
MTIC (Standard) is the analytical standard of MTIC. This product is intended for research and analytical applications. MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1][2][3][4].

HY-16513R

VAL-083 (Standard)	DNA Alkylator/Crosslinker	Cancer
VAL-083 (Standard) is the analytical standard of VAL-083. This product is intended for research and analytical applications. VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.

HY-13703

Nimustine	Apoptosis DNA Alkylator/Crosslinker DNA/RNA Synthesis p38 MAPK JNK AP-1	Cancer
Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity .

HY-13567S1

Bendamustine-d8 SDX-105-d₈ free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-B0077R

Bendamustine hydrochloride (Standard) SDX-105 (Standard)	Reference Standards DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-131085

Desmethyl Vc-seco-DUBA	Drug-Linker Conjugates for ADC	Cancer
Desmethyl Vc-seco-DUBA consists a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA). Desmethyl Vc-seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs) .

Cat. No.	Product Name	Type

HY-W004702

Methyl methanesulfonate	Biochemical Assay Reagents
Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W015854

Ethyl methanesulfonate

Biochemical Assay Reagents

Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc .

Cat. No.	Product Name	Target	Research Area

HY-105019

Melflufen Melphalan flufenamide	DNA Alkylator/Crosslinker Apoptosis	Cancer
Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15366

N-Acetoxy-IQ	Structural Classification Alkaloids Animals Source classification Quinoline Alkaloids	DNA Alkylator/Crosslinker
N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to *DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA* adducts. N-Acetoxy-IQ is promising for research of cancers .

HY-N9279

Dehydromonocrotaline Monocrotaline pyrrole; MCTP; 3,8-Didehydromonocrotaline	Pyrrolizidine Alkaloids Structural Classification Alkaloids Source classification Endogenous metabolite	DNA Alkylator/Crosslinker
Dehydromonocrotaline (Monocrotaline pyrrole) is the metabolite of Monocrotaline (HY-N0750). Dehydromonocrotaline is an alkylating agent, that reacts with DNA, exhibits cytotoxicity, and induces liver and lung damage .

HY-12457

Rachelmycin CC-1065; NSC 298223	Structural Classification Classification of Application Fields Source classification Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Anticancer Disease Research Fields Cancer	Antibiotic DNA/RNA Synthesis
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-17364S

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-W701673

Thio-TEPA-d12
Thio-TEPA-d₁₂ is the deuterium labeled Thio-TEPA (HY-17574). Thio-TEPA is a DNA alkylating agent, with antitumor activity.

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-W738282

Bendamustine-d7 hydrochloride
Bendamustine-d₇ hydrochloride (SDX-105-d₇) is the deuterium labeled Bendamustine hydrochloride (HY-B0077). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-W717139

N-Nitroso-N-methylurea-d5

N-Nitroso-N-methylurea-d₅ is the deuterium labeled N-Nitroso-N-methylurea (HY-34758). N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .

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