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Results for "

Cyclin-dependent kinase 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (11) Akt (2) P-glycoprotein (1) PKA (1) PKC (1) PROTACs (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: CDK Cyclin G-associated Kinase (GAK) CDKL Apical Sodium-Dependent Bile Acid Transporter CaMK PKG SNIPERs DNA-PK VDAC SGLT PDK-1 Pyruvate Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112358

GW8510	CDK	Neurological Disease Cancer
GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities .

HY-108136A

Bisindolylmaleimide X hydrochloride 2 Publications Verification BIM-X hydrochloride; Ro31-8425 hydrochloride	PKC CDK	Cardiovascular Disease
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective *protein kinase* C (PKC)** inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC₅₀ of 200 nM .

HY-162683

(S)-PHA533533	CDK	Neurological Disease Cancer
(S)-PHA533533 is a cyclin-dependent kinase 2 (CDK2) inhibitor. (S)-PHA533533 shows anti-tumor activity and can induce widespread neuronal UBE3A expression in angelman syndrome model mice .

HY-163814

CDK2 degrader 1	PROTACs CDK	Cancer
CDK2 degrader 1 (Compound 3) is an orally active cyclin-dependent kinase 2 (CDK2) degrader based on PROTAC technology. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers (Red: spiro[3.3]heptan-2- ylmethyl carbonochloridate; Blue: N,N-diisopropylethylamine; Black: linker) .

HY-161776

P-gp/CDK2-IN-1	P-glycoprotein CDK	Cancer
P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor for is inhibitor for P-glycoprotein (P-gp) and for **cyclin-dependent kinase-2 (CDK2). P-gp/CDK2-IN-1 inhibits the proliferation of cancer cells SW-480 and MCF-7 wit IC₅₀ of 38.6 μM and 26.6 μM. P-gp/CDK2-IN-1 exhibits antioxidant efficacy with EC₅₀** of 580 μM in DPPH experiment .

HY-162270

CDK2-IN-24	CDK	Cancer
CDK2-IN-24 (compound 3f) is an inhibitor of **cyclin-dependent kinase 2** with an elevated binding energy value .

HY-168057

PROTAC CDK2 Degrader-1	PROTACs CDK	Cancer
PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC₅₀ of 100-500 nM .

HY-148868

Akt1&PKA-IN-1	Akt PKA CDK	Others
Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC₅₀ values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2) .

HY-148868A

Akt1&PKA-IN-2	Akt CDK	Cancer
Akt1&PKA-IN-2 ((R)-29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2 ^a with IC₅₀ values of 0.007 µM, 0.01 µM and 0.69 µM, respectively .

HY-173310

CDK2-IN-44	CDK	Cancer
CDK2-IN-44 (Compound 46) is an inhibitor of cyclin-dependent kinase 2 (CDK2). CDK2-IN-44 can effectively inhibit the proliferation of cancer cells and exert its activity in inhibiting cancer cell growth by arresting the cell cycle, promoting Apoptosis, and inducing cellular senescence. CDK2-IN-44 holds promise for use in the research of ovarian cancer and breast cancer .

HY-170897

CDK2-IN-40	CDK	Cancer
CDK2-IN-40 is a CDK2 (Cyclin dependent kinase 2) inhibitor, extracted from patent WO 2024/254245 A1 (Example 1). CDK2-IN-40 inhibits *CDK2*/Cyclin E1 with an IC₅₀ of ≤ 10 nM .

Recombinant Proteins Recommended:

Cyclin-Dependent Kinase 2 (CDK2)

Species:	Human (9)
Tag:	His (9) GST (9) Flag (8)
Source:	HEK293 (1) Sf9 insect cells (9) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70014

	CDK2 Protein, Human (His) rHuCyclin-dependent kinase 2/CDK2, His; Cyclin-dependent kinase 2; Cell Division Protein kinase 2; p33 Protein kinase; CDK2; CDKN2	Human	E. coli
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702676

	CDK2-CCND1 Protein, Human (sf9, GST, Flag, His) CDK2; Cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2)	Human	Sf9 insect cells
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2-CCND1 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK2-CCND1, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P702675

	CDK2-CCNA2 Protein, Human (sf9, GST, His) CDK2; Cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2)	Human	Sf9 insect cells
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2-CCNA2 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK2-CCNA2, expressed by Sf9 insect cells, with N-6*His, N-GST labeled tag.

HY-P702677

	CDK2-CCNE1 Protein, Human (sf9, GST, His, Flag) CDK2; Cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2)	Human	Sf9 insect cells
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2-CCNE1 Protein, Human (sf9, GST, His, Flag) is the recombinant human-derived CDK2-CCNE1, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P702678

	CDK2-CCNE2 Protein, Human (sf9, GST, Flag, His) CDK2; Cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2)	Human	Sf9 insect cells
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2-CCNE2 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK2-CCNE2, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P702679

	CDK2-CCNO Protein, Human (sf9, GST, Flag, His) CDK2; Cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2)	Human	Sf9 insect cells
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2-CCNO Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK2-CCNO, expressed by Sf9 insect cells, with N-GST, N-Flag, N-His labeled tag.

HY-P703459

	CDK2/CCNE2 Protein, Sus scrofa (Active, sf9, GST, His, Flag) Cyclin-dependent kinase 2; Cell division protein kinase 2; CDK2; Sus scrofa; Pig; kinase; Serine/threonine-protein kinase; Transferase; 2.7.11.22	Others	Sf9 insect cells
	CDK2/CCNE2 Protein, Sus scrofa (Active, sf9, GST, His, Flag) is the recombinant CDK2/CCNE2, expressed by sf9 insect cells , with His, GST, Flag labeled tag. ,

HY-P703475

	CDK2-CCNE1 Protein, Sus scrofa (Active, sf9, GST, His, Flag) Cyclin-dependent kinase 2; Cell division protein kinase 2; CDK2; Sus scrofa; Pig; kinase; Serine/threonine-protein kinase; Transferase; 2.7.11.22	Others	Sf9 insect cells

HY-P702697

	CDK17-CCNY Protein, Human (sf9, GST, Flag) CDK17; Cyclin-dependent kinase 17; PCTAIRE protein kinase 2 , PCTK2; PCTAIRE2; PCTAIRE-motif protein kinase 2; cell division protein kinase 17; protein kinase cdc2-related PCTAIRE-2; serine/threonine-protein kinase PCTAIRE-2; PCTK2;	Human	Sf9 insect cells
	CDK17-CCNY Protein, Human (sf9, GST, Flag) is the recombinant human-derived CDK17-CCNY, expressed by Sf9 insect cells , with GST, Flag labeled tag. ,

HY-P702695

	CDK15-CCNY Protein, Human (sf9, GST, Flag) CDK15; Cyclin-dependent kinase 15; ALS2CR7, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 , PFTAIRE protein kinase 2 , PFTK2; PFTAIRE2; PFTAIRE protein kinase 2; cell division protein kinase 15; serine/threonine protein kinase; serine/threonine-protein kinase ALS2CR7; serine/threonine-protein kinase PFTAIRE-2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein; PFTK2; ALS2CR7	Human	Sf9 insect cells
	The CDK15ic protein, functioning as an antiapoptotic kinase, counteracts TRAIL/TNFSF10-induced apoptosis by phosphorylating BIRC5 at 'Thr-34'. This regulatory role crucially inhibits programmed cell death triggered by TRAIL/TNFSF10, highlighting the heterodimer's active contribution to antiapoptotic signaling. CDK15-CCNY Protein, Human (sf9, GST, Flag) is the recombinant human-derived CDK15-CCNY, expressed by Sf9 insect cells , with GST, Flag labeled tag. ,

HY-P7850

	CDK2AP2 Protein, Human (HEK293, His) rHuCyclin-dependent kinase 2-associated protein 2/CDK2AP2, His; Cyclin-dependent kinase 2-associated protein 2; CDK2-associated protein 2; DOC-1-related protein; DOC-1R; CDK2AP2; DOC1R	Human	HEK293
	The CDK2AP2 protein is an important component of the NuRD complex and actively participates in chromatin remodeling. It inhibits the G1/S phase transition by inhibiting CDK2 and preventing the interaction of CDK2 with cyclin E or A. CDK2AP2 Protein, Human (HEK293, His) is the recombinant human-derived CDK2AP2 protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P80798

	Phospho-CDK2 (Tyr15) Antibody (YA217) CDK2; CDKN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase	WB, IP	Human, Hamster, Rat
	Phospho-CDK2 (Tyr15) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Phospho-CDK2 (Tyr15). It can be used for WB,IP assays with tag free, in the background of Human, Hamster, Rat.

HY-P86535

	CDK2 Antibody (YA6227) CDK2; CDKN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CDK2 Antibody (YA6227) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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