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BTK-IN-11

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147581
    BTK-IN-11

    		Btk Inflammation/Immunology Cancer
    BTK-IN-11 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-11 has the potential for the research of related diseases, especially autoimmune diseases, inflammatory diseases or cancer (extracted from patent WO2022063101A1, compound Z2) .
    BTK-IN-11
  • HY-159947
    PROTAC BTK Degrader-11

    		PROTACs Btk Cancer
    PROTAC BTK Degrader-11 is a PROTAC degrader that can break down BTK, with a DC50 of 1.7 nM. PROTAC BTK Degrader-11 can be used in cancer research. (Pink: target protein ligand (HY-159956); Black: linker; Blue: E3 ligase (HY-150839)) .
    PROTAC BTK Degrader-11
  • HY-168314
    BTK ligand 11

    		Ligands for Target Protein for PROTAC Cancer
    BTK ligand 11 is a PROTAC target protein ligand that can be used to synthesize BCPyr (HY-142621) .
    BTK ligand 11
  • HY-159956
    BTK-IN-39

    		Ligands for Target Protein for PROTAC Cancer
    BTK-IN-39 (0204) is a PROTAC target protein ligand that can be used to synthesize PROTAC BTK Degrader-11 (HY-159947) .
    BTK-IN-39
  • HY-142621
    BCPyr

    		PROTACs Btk Cancer
    BCPyr is a PROTAC-class BTK degrader (DC50 = 800 nM) . BCPyr consists of a PROTAC target protein ligand (red part) BTK ligand 11 (HY-168314), an E3 ubiquitin ligase ligand (blue part) E3 ligase Ligand 20 (HY-135997), and a PROTAC linker (black part) (5-(Bromomethyl)pyrazin-2-yl)methanol (HY-168315). E3 ubiquitin ligase+linker can form E3 Ligase Ligand-linker Conjugate 146 (HY-168316).
    BCPyr

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