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Albino mice

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Biochemical Assay Reagents

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156277
    SP4f

    		PPAR Metabolic Disease
    SP4f is an activator ofPPAR-γ, with the EC50 of 826 nM in HK-2 cells. SP4f reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .
    SP4f
  • HY-148456
    Anti-inflammatory agent 34

    		Others Inflammation/Immunology
    Anti-inflammatory agent 34 (Compound IVf) is an orally active anti-inflammatory and analgesic agent .
    Anti-inflammatory agent 34
  • HY-34596
    4-Hydroxyindole

    		Biochemical Assay Reagents Amyloid-β Neurological Disease Metabolic Disease
    4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders .
    4-Hydroxyindole
  • HY-A0021
    Palonosetron hydrochloride
    1 Publications Verification

    		 5-HT Receptor Flavivirus Cardiovascular Disease Cancer
    Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity .
    Palonosetron hydrochloride
  • HY-156276
    SP4e

    		PPAR Metabolic Disease
    SP4e is an activator of PPAR-γ, with the EC50 of 739 nM in HK-2 cells. SP4e reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .
    SP4e
  • HY-108281
    Enfenamic acid

    Tromaril; RH 8

    		 Others Inflammation/Immunology
    Enfenamic acid is a nonsteroidal anti-inflammatory agent and a prostaglandin synthetase inhibitor, inhibiting hepatic gluconeogenesis in Swiss albino mice. Enfenamic acid suppresses wound healing .
    Enfenamic acid
  • HY-146704
    COX-2/sEH-IN-1

    		Epoxide Hydrolase COX Cardiovascular Disease
    COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks .
    COX-2/sEH-IN-1
  • HY-146058
    NF-κB/PON1-IN-1

    		NF-κB Reactive Oxygen Species Cancer
    NF-κB/PON1-IN-1 (Compound 16) is a NF-κB/PON1 pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC50 = 45.76 µM) and hepatoprotective activities .
    NF-κB/PON1-IN-1
  • HY-N12398
    Psychotridine

    		Others Neurological Disease
    Psychotridine is a natural alkaloid isolated from Psychotria colorata, reveals an analgesic activity in nervous system and an inhibitory efficacy towards platelet aggregation .
    Psychotridine
  • HY-161243
    AChE-IN-56

    		Cholinesterase (ChE) Neurological Disease
    AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy .
    AChE-IN-56
  • HY-B2209B
    Hydroxocobalamin acetate
    3 Publications Verification

    Vitamin B12a acetate

    		 NO Synthase Cardiovascular Disease Metabolic Disease
    Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia .
    Hydroxocobalamin acetate
  • HY-139414
    Lysophosphatidylcholines
    1 Publications Verification

    		 Interleukin Related p38 MAPK ERK Apoptosis Inflammation/Immunology
    Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .
    Lysophosphatidylcholines
  • HY-162606
    MAO-A/B-IN-3

    		Monoamine Oxidase Cholinesterase (ChE) Neurological Disease
    MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC50 values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases .
    MAO-A/B-IN-3
  • HY-158261
    AChE-IN-63

    		Cholinesterase (ChE) Amyloid-β Beta-secretase Neurological Disease
    AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research .
    AChE-IN-63
  • HY-162761
    COX-1/2-IN-9

    		Bacterial COX Inflammation/Immunology
    COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states .
    COX-1/2-IN-9
  • HY-B1178R
    Cotinine (Standard)

    		Endogenous Metabolite nAChR Cardiovascular Disease Inflammation/Immunology
    Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke
    Cotinine (Standard)
  • HY-B1178
    Cotinine
    1 Publications Verification

    (-)-Cotinine; (S)-Cotinine; NIH-10498

    		 Endogenous Metabolite nAChR Cardiovascular Disease Inflammation/Immunology
    Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .
    Cotinine
  • HY-B0900
    Anethole
    1 Publications Verification

    Anise camphor; p-Propenylanisole; Isoestragole

    		 Apoptosis Fungal Bacterial MMP NF-κB Infection Neurological Disease Inflammation/Immunology Cancer
    Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .
    Anethole

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